Saturday, 31 July 2021

Overview of Pediatric Nonalcoholic Fatty Liver Disease with a Focus on Histology | Chapter 14 | Highlights on Medicine and Medical Science Vol. 9

 Nonalcoholic fatty liver disease (NAFLD) is a disorder in which a person's liver accumulates excessive fat despite never having consumed excessive alcohol. Simple steatosis and nonalcoholic steatohepatitis are two types of this disease (NASH). NAFLD/NASH is the hepatic manifestation of the metabolic syndrome. The prevalence of paediatric NAFLD has increased in recent years, along with the prevalence of childhood obesity. Pediatric NAFLD is thought to affect between 2.6 and 9.6 percent of children, and it is associated to sex, age, and ethnicity. When it comes to the aetiology of NAFLD, the "two-hit" model is widely accepted, and oxidative stress is thought to play a crucial role in the second hit. Despite the importance of clinical symptoms, test data, and imaging studies in diagnosing NAFLD/NASH, liver biopsy remains the gold standard. Furthermore, a liver biopsy is required to determine the degree of necro-inflammatory alteration and fibrosis in NASH patients. Type 1 and type 2 NASH are the two types of steatohepatitis, with type 2 NASH being present in up to 51% of juvenile NAFLD patients. However, as we and others have observed, type 1 and 2 patterns frequently overlap. Despite the fact that medicine has been studied in clinical trials, the core of NAFLD/NASH treatment remains diet and exercise.

Author(s) Details

Yoshihisa Takahashi
Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.

Toshio Fukusato
Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.

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The Importance of Liver Fatty Acid-Binding Protein Downregulation in Hepatocellular Carcinoma| Chapter 13 | Highlights on Medicine and Medical Science Vol. 9

 The goal of this study was to see how significant it was in hepatocellular carcinoma for the expression of liver fatty acidbinding protein (L-FABP) to be downregulated (HCC). Methods: On tissue microarrays from 146 cases of HCC, immunohistochemical labelling for L-FABP was conducted. Further immunohistochemical staining was done on a representative whole-tissue section for each L-FABP-negative HCC to validate the downregulation of L-FABP expression and examine intratumoral heterogeneity of the staining pattern. Clinical data was acquired from the clinical files and histological slides were inspected. Immunohistochemical staining for cytokerati on tissue microarrays There was also a test for serum amyloid A (SAA). Clinicopathological characteristics of L-FABP-negative and L-FABP-positive HCC patients were compared. In addition, real-time reverse transcription polymerase chain reaction was used to examine L-FABP and GS gene expression in HCC and cholangiocarcinoma (CC) cell lines. For L-FABP-negative HCC cases, mutation analysis of HNF1A (encoding hepatocyte nuclear factor 1 (HNF1)) was done. Sixteen of the 146 HCC patients (10.9 percent) were negative for L-FABP. When we looked at the relationship between L-FABP downregulation and tumour size, we found that most cases of smaller HCC (less than 2 cm in diameter) had localised downregulation, while most cases of bigger HCC (more than 2 cm in diameter) had diffuse downregulation. The connection (P = 0.036) was statistically significant. The L-FABP-negative area commonly resembled a "nodule-in-nodule" look when the HCC was smaller. Tumor differentiation was much lower, and the frequency of intratumoral inflammation was significantly lower in L-FABP-negative cases than in L-FABP-positive cases in small HCC cases. Cases with FABP positivity (P = 0.032 and 0.009, respectively). L-FABP-negative instances of small HCC had a considerably greater frequency of -catenin and GS staining than L-FABP-positive cases of small HCC (P = 0.009 and P = 0.000, respectively). Four of the six HCC cell lines studied had increased L-FABP expression, whereas the remaining two had lower or no L-FABP expression. A mutation in exon 4 of HNF1A was found in two of the 16 L-FABP-negative HCC cases. Conclusion: L-FABP downregulation occurs in smaller HCCs due to phenotypic changes as the tumour progresses. Furthermore, this downregulation was linked to tumour differentiation and inflammation within the tumour.

Author(s) Details

Masafumi Inoue
Department of Pathology, Toranomon Hospital, Tokyo 105-8470, Japan.

Yoshihisa Takahashi

Department of Pathology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Takeshi Fujii
Department of Pathology, Toranomon Hospital, Tokyo 105-8470, Japan.

Masanobu Kitagawa
Department of Comprehensive Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Toshio Fukusato
Department of Pathology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.


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Evaluation of Vitamin D Status, Selenium & CRP Level in Psoriasis | Chapter 12 | Highlights on Medicine and Medical Science Vol. 9

 Psoriasis is an inflammatory skin disease that is linked to a variety of medical issues.  It is caused by a mix of genetic predisposition and environmental circumstances, which cause immune system sensitivity.  The goal of this study is to determine the status of serum vitamin D, selenium, and CRP levels in psoriasis patients, as well as their relationship to disease severity. Materials and Methods: This hospital-based case-control study included 50 psoriasis cases and 47 healthy persons. Serum VD, selenium, and CRP levels, as well as general demographic data, were also measured. According to statistical analysis, VD levels are significantly lower in psoriasis (p 0.005). In terms of demographic characteristics, psoriasis patients were found to be more obese than controls. The serum levels of selenium and CRP were not substantially different between the two groups. Conclusion: Vitamin D insufficiency is highly linked to psoriasis, according to our findings. Vitamin D supplementation can aid in the treatment of psoriasis and the reduction of obesity. In our research, serum selenium and CRP levels were found to have minimal significance.

Author(s) Details

S. Sumathi
Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, SBV, Pondicherry, India.

Dr. S. Vinod Babu
Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute, SBV, Pondicherry, India.

Dr. K. Karthikeyan
Department of Dermatology, Sri Manakula Vinayagar Medical College & Hospital, Pondicherry, India.

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Study on Correlation between Troponin-I Level with Left Ventricular Systolic Dysfunction after First Attack of Non-ST Segment Elevation Myocardial Infarction | Chapter 11 | Highlights on Medicine and Medical Science Vol. 9

 Background: Coronary Heart Disease (CHD) is the most common type of heart disease, and it is the leading cause of death in the developed world. It's crucial to recognise an ACS patient because the diagnosis triggers both triage and treatment. CHD is the cause of more than half of all cardiovascular disease in people. cTnI is a myocardium-specific tissue marker that has been shown to be both sensitive and specific for AMI. Ventricular function is the best predictor of death after an ACS. It's a myocardial damage indicator that also tells you about systolic function, diagnosis, and prognosis. The study's goal was to see if LVEF had an effect on high Troponin-I levels in patients who were having their first NSTEMI event. A cross-sectional analytical study was conducted in the cardiology department of Mymensingh Medical College Hospital from December 2015 to November 2016. A total of 130 first-time NSTEMI patients were included in the study, based on inclusion and exclusion criteria. Two groups of people were chosen from the sample population: Patients in Group I had their first NSTEMI episode and had an LVEF of less than 55%. Group–II: Patients who have had their first NSTEMI incident and have an LVEF of less than 55%. Then, using Pearson's correlation coefficient test, the levels of LVEF and Troponin-I were connected. The mean Troponin-I levels in groups I and II were 5.537.33 and 16.4615.79 ng/ml, respectively, in this investigation. There was a statistically significant difference (p0.05). The mean LVEF for the two groups was 65.3110.30 percent and 40.174.62%, respectively. There was a statistically significant difference (p 0.05). According to echocardiography, patients with a high Troponin-I level had a poor LVEF, while those with a low Troponin-I level had a preserved LVEF. Patients with the highest Troponin-I levels had severe left ventricular systolic dysfunction (LVEF 35%), while those with the lowest levels had severe left ventricular systolic dysfunction (LVEF 35%). Troponin-I levels were low, although systolic function was intact (LVEF was 55%). Troponin-I levels displayed a negative correlate with LVEF levels with a medium strength of association (r= -0.5394, p=0.001), according to our findings. Troponin-I levels of 6.6 ng/ml were also revealed to be a sensitive and specific marker for LV systolic dysfunction in our investigation. Conclusion: The researchers discovered that in NSTEMI patients with their first attack, the higher the Troponin-I level, the lower the LVEF level, and therefore the more severe the LV systolic dysfunction.


Author(s) Details

Dr. Mahmood Hasan Khan
Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.

Mirza Md. Nazrul Islam
Department of Cardiology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh.

Md. Shafiqul Islam
Department of Epidemiology, National Institute of Preventive & Social Medicine (NIPSOM), Dhaka, Bangladesh.

Kaisar Nasrullah Khan
Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.

Md. Shamim Chowdhury

Department of Cardiology, National Heart Foundation Hospital & Research Institute, Bangladesh.

Reazur Rahman
Department of Cardiology, United Hospital Limited, Dhaka, Bangladesh.


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Determination of Eruptive Fevers in the Infectious Diseases Department of Ouagadougou CHU-YO, Burkina Faso from 2005 to 2019 | Chapter 10 | Highlights on Medicine and Medical Science Vol. 9

 Infectious cutaneous diseases are a major public health issue in tropical environments. In the Infectious Diseases Department of CHU YO, describe the epidemiological, clinical, therapeutic, and evolutionary aspects of eruptive fevers. Patients and Procedures: The research took place at the Yalgado Ouedraogo University Hospital Center's Department of Infectious and Tropical Diseases. From January 1, 2005, to December 31, 2019, a descriptive retrospective analysis of cases of eruptive fever hospitalised in the department was conducted. Eruptive diseases were found to be prevalent in 5% of the population over the study period. Patients ranged in age from one to seventy-three years old on average. With a sex ratio of 1.4, the most represented age group was 01- 14 years old (53.1 percent). Only 27.2 percent of patients had had their measles vaccination. The most common syndrome was a combination of fever and cough (26.2 percent ). Maculopapular lesions were the most common elemental lesions (46.2%), followed by vesicular lesions (10 percent ). Measles (50.8 percent), herpes (19.2 percent), chickenpox (14.6 percent), HIV infection (6.3 percent), and meningitis were the most common pathologies involved (6.1 percent ). Hospitalization lasted an average of 7.5 days, with extremes of 1 and 26 days. The fatality rate was 4.6%. Conclusion: Measles and chickenpox are still causing outbreaks in Burkina Faso communities. It is critical to raise immunisation awareness against these febrile eruptive illnesses.


Author(s) Details

Dr. Savadogo Mamoudou
Department of Infectious Diseases, Yalgado Ouedraogo University Hospital, and UFR / SDS of Joseph Ki Zerbo University, Burkina Faso.

Diallo Ismaël
Internal Medicine Department, Yalgado Ouédraogo University Hospital, and UFR / SDS of Joseph Ki Zerbo University, Burkina Faso.

Sondo K. Apoline
Department of Infectious Diseases, Yalgado Ouedraogo University Hospital, and UFR / SDS of Joseph Ki Zerbo University, Burkina Faso.

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Pharmacotherapeutic Options for Management of Attention Deficit Hyperactivity Disorder| Chapter 9 | Highlights on Medicine and Medical Science Vol. 9

 The most frequent behavioural disorder in children is attention deficit hyperactivity disorder (ADHD). ADHD can make a person unable for the rest of their lives. The Diagnostic and Statistical Manual of Mental Disorders is used to diagnose ADHD (DSM-5). ADHD is a costly health concern that has been treated with a variety of medicines, including psychostimulants, tricyclic antidepressants (TCAs), bupropion, pemoline, clonidine, and atomoxetine. The most typically recommended medicines for paediatric ADHD are atomoxetine and psychostimulants, both of which have equal efficacy. Atomoxetine has been linked to a number of serious side effects. There have been some reports. Modafinil, a mild psychostimulant, is not approved by the US Food and Drug Administration to treat ADHD, but it is prescribed off-label for this illness. Concurrent psychiatric diseases, such as sleeplessness, tics, PTSD, and violence, necessitate extra consideration while managing a person with ADHD.


Author(s) Details

Jarnail Singh Braich
Department of Pharmacology, Pt. BD Sharma UHS, Rohtak, Haryana, India.

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Evaluating the Drug Utilization in Ophthalmology Outpatients at a Tertiary Care Teaching Hospital | Chapter 8 | Highlights on Medicine and Medical Science Vol. 9

 The goal of this study was to see how medications were used in the ophthalmology outpatient department. Materials and Procedures: The research was carried out at the ESIC Medical College and the PGIMSR Ophthalmology Department. A total of 700 prescriptions were collected from 700 patients and studied for total and average number of pills per prescription, duration of therapy, dosage form, drug encounters with antibiotics and other drugs, and percentage of pharmaceuticals prescribed by generic names. After reviewing the prescriptions, it was discovered that the average number of medications per prescription was 2.14, with a range of pharmaceuticals prescribed ranging from 1 to 5. There were a total of 1502 medications prescribed, with seven different dose forms. Antibiotics were the most regularly prescribed medication (28.14 percent), followed by antihistamines (14.285), and vitamins and minerals (14.285). (14.28 percent ). Third, lubricants for the eyes were regularly given (12.12 percent ). Antibiotics containing fluoroquinolones (moxifloxacin) were routinely prescribed. The most prevalent prescription writing mistakes were minor.


Author(s) Details

Dr. C. H. Janakidevi
Sri Muthukumaran Medical College Hospital and Research Centre, The Tamilnadu Dr. M.G.R. Medical University, India.

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Electrical Storm and ICD Therapy: An Overview Update | Chapter 7 | Highlights on Medicine and Medical Science Vol. 9

 An electrical storm (ES) is a ventricular arrhythmia (VA) defined as the occurrence of three or more ventricular tachycardias (VT) in a day, separated by five-minute intervals, or the existence of unending VT despite antiarrhythmic drug therapy optimization. The goal of this chapter is to provide an overview of electrical storms in ICD therapy patients. During follow-up, 84 of 1274 patients with an implanted cardioverter-defibrillator (ICD) developed ES, according to the findings. During the first 134 days after ICD implantation, the incidence of ES in individuals with ICD can reach 20%. Because ES can be induced by a variety of factors, the pathophysiological process is unknown. VT and ventricular fibrillation (VF), global acute ischemia, and myocardial dysfunction are just a few of the clinical circumstances and mechanisms that cause myocardial dysfunction. Shocking cardiac death is three times more likely in patients with ES (SCD). Emergency sedation, ventilation, neuraxial modulation, pharmacological therapy (beta-blockers, amiodarone, sotalol, class I anti-arrhythmic medications), and catheter ablation are among the treatment options (CA). CA is a process for rescuing people. When pharmacological therapy has had little or no effect, this procedure is used. This method involves mapping the region first, then choosing between approaches (endocardial or epicardial) and several CA methods, which include radiofrequency ablation, irrigated radiofrequency ablation, pulsed radiofrequency ablation, alcohol ablation, and cryoablation.


Author(s) Details

Prof. Antônio da Silva Menezes Júnior
Federal University of Goiás and Pontifical Catholic University of Goiás, Goiânia, Brazil.

Ana Luisa Adorno de Lima

Pontifical Catholic University of Goiás, Goiânia, Brazil.

Roberta Gomes da Mata
Pontifical Catholic University of Goiás, Goiânia, Brazil.

Dayanne Cardoso Teixeira
Pontifical Catholic University of Goiás, Goiânia, Brazil.

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A Review on Mucosal Immunology of Human Head | Chapter 6 | Highlights on Medicine and Medical Science Vol. 9

 Human head immunity is a three-part system. Natural, cross-roads, and adaptable are all words that come to mind while thinking about this project. It has four immune-system components. Mucosal immune system, mononuclear cell system, systemic transudent cellular entities, and systemic transudent humoral immune proteins are all examples of systemic transudent cellular entities. Such immune-oriented settings for the human head are beneficial in countering local infectious assaults.


Author(s) Details

Prof. Emeritus Dr. Ibrahim M. S Shnawa
Hilla University College, Raringia, Babylon, Iraq and Department of Biotechnology,College of Biotechnology, University of Qasim, Qasim, Babylon, Iraq.

View Book :- https://stm.bookpi.org/HMMS-V9/article/view/2240

Evaluation of the Metabolic Parameters in Women with Gestational Diabetes Mellitus after Delivery: A Comparative Study | Chapter 5 | Highlights on Medicine and Medical Science Vol. 9

 The majority of women with GDM have clinical signs and symptoms that indicate a type 2 diabetes risk (T2D). T2D can be prevented or delayed, according to current data, by making significant lifestyle changes and taking drugs, particularly those that reduce insulin resistance. The obligatory clinical care step in the postpartum period is a glucose tolerance test to diagnose diabetes or assess diabetes risk. All patients should be closely monitored for signs of progressive -cell degeneration, such as rising glycemia. For this, a combination of fasting glucose and glycosylated haemoglobin tests is recommended. Monitoring should be done at least once a year. If glycemia is rising and/or impaired, this should be done on a regular basis. To reduce the risk of T2D, lifestyle changes are recommended. Breastfeeding is also very important for the infant's substantial short- and long-term health benefits; encouraging and assisting breastfeeding mothers lowers the risk of later obesity and glucose intolerance.


Author(s) Details

Dr. Seema Singh
Department of Physiology, Era’s Lucknow Medical College and Hospital, Lucknow, India.

Dr. Nitin Ranjan Gupta

Department of Internal Medicine, Hind Institute of Medical Sciences and Research. Ataria, Mau, Sitapur, India.

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Hematological Involvement in Pediatric Systemic Lupus Erythematosus | Chapter 4 | Highlights on Medicine and Medical Science Vol. 9

 Systemic lupus erythematosus (SLE) is a multisystemic chronic autoimmune disease with a varied clinical history. Hematological involvement is common, and it has been linked to an increase in morbidity and mortality, as well as an increased risk of infection and lower survival rates. The goal of this study was to describe the hematologic changes in paediatric SLE patients when they were first diagnosed. Methods. A retrospective descriptive analysis was undertaken on patients with SLE who were treated at the Exequiel Gonzalez Cortes Children's Hospital's Immunorheumatology Outpatients Center in Santiago, Chile. Thirty-three clinical files were examined, and demographic and clinical information was collected. Results. Thirty patients met the criteria for inclusion, 22 of them were females with an average age of 11.6 years (range 5 to 14). Hematological compromise was seen in 60% of the participants (n = 18). Lympopenia was the most common haematological abnormality, with 14 individuals, followed by autoimmune hemolytic anaemia (HA) with 11 patients. Ten individuals had leukopenia, while three had thrombocytopenia. Lympopenia was found to be associated with leukopenia in 50% of the patients (n = 9) while HA was shown to be associated with lymphopenia in 8 individuals. Skin involvement was the most common extra-hematological manifestation in patients with haematological changes (26/30), followed by kidney involvement (25), articular involvement (22), and serositis (17).

 Conclusions. In this cohort of paediatric SLE cases, haematological involvement was common, and this is accounted for in both classic and contemporary diagnostic criteria. It can be the first symptom in a group of patients, necessitating a differential diagnosis and close monitoring. In other circumstances, it could be a symptom of severe SLE that necessitates aggressive treatment.

Author(s) Details

María-Soledad Ayala
Department of Pediatrics School of Medicine University of Chile, Santiago, Chile.

Ximena Norambuena
Immunorheumatology Unit Children´s Hospital Dr. Exequiel Gonzalez Cortes, Santiago, Chile and Pediatric Rheumatology International Trials Organization (PRINTO) Member, Chile.

Alfonso Loosli
Immunorheumatology Unit Children´s Hospital Dr. Exequiel Gonzalez Cortes, Santiago, Chile.

Arnoldo Quezada
Department of Pediatrics School of Medicine University of Chile, Santiago, Chile and Pediatric Rheumatology International Trials Organization (PRINTO) Member, Chile.

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Differential Diagnosis of Focal Hepatic Lesions Using Ultrasound Confirmed with Histopathology: Recent Advancement | Chapter 3 | Highlights on Medicine and Medical Science Vol. 9

 Over the last few decades, advances in imaging technologies have helped to better characterise hepatic abnormalities. The goal of this study was to distinguish localised hepatic lesions based on ultrasound (U/S) features and compare the results to histology. A descriptive retrospective research of 100 patients with localised hepatic lesions was conducted at King Abdul-Aziz Specialist Hospital in Taif, Saudi Arabia, from 2012 to 2019. Adult Saudi patients aged 18 and up met the inclusion criteria. The investigation used LG-9 and Philips ultrasound equipment with 3.5 MHz transducers. The 55 to 80 year old age group accounted for 44% of the total, with a mean age of 49 years and 92 percent of married people. In histology, 86 percent of well-defined lesions margins were benign (p=0.00), 61 percent of ill-defined margin lesions were malignant (p=0.02), and 73 percent of hyperechoic lesions were hemangioma (p=0.02). When it came to the nature of hepatic lesions during U/S, 87 percent of solid lesions (p=0.03) were malignant, while 89 percent of cystic lesions were benign (p=0.03). Sixty-one percent of hypoechoic lesions were cancerous. Under colour Doppler, 80 percent of vascular lesions were benign. The sensitivity and specificity of the U/S test were 93.5 percent and 98 percent, respectively. U/S is a valuable tool for distinguishing cystic hepatic lesions from solid lesions in the liver. (p=0.03). To create a data base for hepatic lesions, comparable studies with large samples must be conducted in the Taif region. With a high degree of sensitivity and specificity, the majority of chosen hepatic lesions with suspicious characteristics were confirmed as malignant in histopathology.


Author(s) Details

Dr. Rania Mohammed Ahmed
Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, KSA.

Ms. Sharifah Alkathiri
Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, KSA.

Ms. Waad Altalhi
Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, KSA.

Ms. Hatun Eid
Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, KSA.

Ms. Manar Alshalawi
Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, KSA.

Ms. Sara Alotaibi
Department of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif, KSA.

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Prognostic Factors and Postoperative Survival in Clear Cell Renal Carcinomas. A Histopathological Diagnosis| Chapter 2 | Highlights on Medicine and Medical Science Vol. 9

 Introduction: a cell that is clear The most prevalent kind of Renal Cell Carcinoma that arises in adulthood is ccRCC, which has the worst prognosis among the major epithelial cancers of these organs. A high blood supply characterises this neoplasm. In light of this, we used CD34, an endothelial antigen that has previously been used to highlight microvessel density (MVD), as a direct marker of neoangiogenesis degree. The goal of this study was to see if there was a link between CD34 and other prognostic indicators such Fuhrman nuclear degree and tumour size. Material and Methods: Tumour tissues from 17 individuals with a histopathological diagnosis of ccRCC were stained for CD34 using immunohistochemistry. Anova and Student Newman Multiple Comparison Test with Tuckey as a post-test were used to examine CD34 expression, and then we utilised a Spearman Correlation to compare it to the other prognostic markers studied, as well as Kaplan Meier survival analysis for the patients' disease-free survival. The MVD has a negative association with the Fuhrman nuclear grade, with R = -0,46 and p = 0,05, and a positive correlation with the maximum tumour diameter, with R = 0,47 and p = 0,05. Finally, we discovered that a high MVD is associated with a low Fuhrman nuclear grade and a large tumour size. The relevance of this research could be that we require more than one parameter to predict the ccCCR's biological behaviour.


Author(s) Details

P. Colaci
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina and Hospital Zonal General de Agudos “Evita Pueblo”, Berazategui, Bs. As., Argentina.

A. L. Errecalde
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.

A. M. Inda
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.

M. Garcia
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.


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Cystic Malformation of Cystic Duct: A Study of 10 Cases with Review of the Literature | Chapter 1 | Highlights on Medicine and Medical Science Vol. 9

 The goal of this test is to see if there are any cystic abnormalities in the cystic duct. We found 10 occurrences of cystic malformation of the cystic duct in patients who had their abdominal complaints investigated in our radiology department with ultrasonography, multidetector computed tomography, or magnetic resonance imaging over the course of two years. A dilated, nonvascular cystic structure near the porta hepatis and visualisation of a clear communication with the gallbladder, normal calibre cystic duct, and/or common bile duct (CBD) on at least one imaging modality were used to make a radiological diagnosis of cystic malformation of the cystic duct. In four of 10 cases, the cystic duct demonstrated saccular dilatation. Six individuals had fusiform dilatation of the cystic duct, with two of them having just minor dilatation. CBD dilatation was seen in two of the individuals, whereas the third developed cystic duct calculi and malignancy. Conclusion: Cystic duct abnormalities should be recognised as a distinct type of choledochal cyst and classified as type VI cysts by Todani.


Author(s) Details

Dr. Praveen Maheshwari
Specialist Radiologist, Abu Dhabi, United Arab Emirates.

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MBBS – Pharmacology Practical Book | Book Publisher International

 The goal of this book, titled "MBBS-Pharmacology Practical Book," is to assist second-year MBBS students in learning Pharmacology through practical activities and applying what they've learned in Pharmacology to disease therapy.


Clinical pharmacy (CP), Clinical pharmacology (CPH), Experimental pharmacology (EPH), and Communication (C) are the 28 pharmacology practical tasks specified in the new undergraduate CBME curriculum to obtain the 21 competencies defined in the CBME syllabus. Among these, students must obtain certification in four clinical pharmacology abilities, including the ability to write a rational prescription, critically analyse a written prescription and drug promotional literature, and contribute to India's pharmacovigilance programme.

Taking into account the above requirements, necessary exercises for identifying and evaluating drug formulations, drug administration via various routes using mannequins, drug dosage calculation in various age groups and disease states, clinical problem-solving exercises, prescription writing, prescription audit, pharmacoeconomic, and pharmacovigilance exercises, as well as clinical problem-solving exercises, prescription writing, prescription audit, pharmacoeconomic, and pharmacovigilance exercises, have been developed.

Finally, these exercises can help students learn how to select and use various drug formulations in the proper dosage and combination for the proper patient through sensible prescriptions. The simulations also teach students how to administer medications and communicate successfully with patients and the general public about drug usage.

Author(s) Deatails

Dr. A. Ruckmani
Professor and Head, Department of Pharmacology, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chengalpattu District, Tamilnadu, 603103, India.

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Basics of Nanoscience, Nanomaterials and Nanotechnology | Book Publisher International

 The first chapter of this book begins with a definition of nano, nanoscale, and nanometer, as well as an introduction to the current period of Nanoscience, nanomaterials, and nanotechnology. The literature abstract is organised into parts and subsections and is provided as a sequential text. In summary, some examples have been used to demonstrate how bulk and nanomaterials differ based on the size of particles used as building blocks. The physical and chemical properties of the same substance in bulk and nanoform have been shown to fluctuate dramatically depending on particle size. There is also a distinction between nanoscience and nanotechnology. Nanomaterials are classified as 3D, 2D, 1D, and 0D materials due to the reduction in particle size (dimensions). It has been attempted to classify nanomaterials by accurately defining them with figures. The literature on what morphology is, how morphology helps to classify synthesised nanomaterials, and the usefulness of morphology for researchers and scientists to locate the right application field for synthesised nanomaterials can be found in the morphology section. In chapter 2, a brief introduction to electron microscopes, such as SEM and TEM, has been given to analyse the morphology of nanomaterials, and its detailed theory has been given. There are also some examples of nanomaterial morphology. Later in the manuscript, the merits and disadvantages of top-down and bottom-up methodologies for nanomaterial fabrication are discussed. The physical and chemical properties of nanomaterials have been briefly discussed as a function of particle size. The surface to volume ratio, quantum confinement, and reduced structural imperfection or flaws of nanomaterials are all stated. Then, a focus on particle size dependent physical properties of nanomaterials, such as structural, thermal, magnetic, optical, electronic, and electrical properties, as well as the causes for each property, was placed. By addressing specific numerical issues, distinctive properties of nanomaterials such as surface area to volume ratio and quantum confinement become prevalent when particle size decreases. After then, the nanocluster hypothesis was presented in full. The first chapter concluded with theory on 2D nanomaterials (Quantum wells), 1D nanomaterials (Quantum wires), and 0D nanomaterials (Nanoparticles - Nanoclusters, Quantum dots, and Buckyballs), as well as detailed theory on some special nanomaterials, such as fullerenes (0D nanomaterials), carbon nanotubes (1D nanomaterials), and graphene (2D nanomaterial). The second part of this book begins with an overview of nanotechnology, covering what it is, how it came to be, when the concept of nanotechnology became popular, its benefits, goals, and key elements. The gas (vapour) phase fabrication and liquid phase fabrication are highlighted as the two approaches that belong to the bottom-up approach after introducing two primary ways (top-down and bottom-up) for nanomaterial preparation. The theory of various methods for the synthesis of nanomaterials, such as chemical vapour deposition (CVD - Gas Phase Fabrication), Sol-gel method, and hydrolyzed colloid reaction (HCR) technique (wet chemical methods - Liquid Phase Fabrications), has been explained in detail under the heading of bottom-up approach. A thorough description of how to determine the particle size of nanomaterials using the BET theory and the Debye-Scherrer method for X-Ray diffraction patterns has been provided. Then, to examine the morphology and internal structure of nanomaterials, the s theory on electron microscopy, detail theory on scanning electron microscope (SEM), and transmission electron microscope (TEM) were introduced. The second chapter concluded with several applications of nanomaterials in various fields, nanotechnology issues, and numerical problems that were solved.


Author(s) Details

Upendra B. Mahatme
Department of Physics, K. Z. S. Science College, Bramnhi- Kalmeshwar, R.T.M. Nagpur University, India.

View Book:- https://stm.bookpi.org/BNNN/article/view/2483

Natural Medicinal Flora of Three Gorges of Yangtze River (Part of Rare and Endangered Medicinal Plants) | Book Publisher International

 The natural medicinal flora of the Yangtze River's three gorges was the subject of this book. This book seeks to give academics and practitioners of traditional Chinese medicine with information on natural medicinal plants found in China's Three Gorges region. This book examines the natural environment, vegetation composition, distribution law, and floristic composition of natural medicines in depth, based on a systematic field examination of natural medicinal plants in China's Three Gorges region. The book serves as a useful guide for experts and may also be utilised as a reference book.


Author(s) Details

Shaocheng Chen
Chongqing University of Education, China.

Xin Zhao
Chongqing University of Education, China.

Jianhong Ke
Chongqing Academy of Agricultural Sciences, China.

View Book:- https://stm.bookpi.org/NMFTGYR/article/view/2439

Rooftop Solar Photo Voltaic Power Plant Design and Analysis with PVSyst Software | Book Publisher International

 Rooftop solar panels Solar panels are increasingly being used to generate electricity in photovoltaic systems around the world. The design of a power plant for solar roof top generation to install a 33KWp on-grid solar power system with Latitude 16.54°N and Longitude 81.50°E for the grid connected PV system is installed at an area of 345 sq. m and the PV modules are tilted at an angle of 18° on the top of a three-story building This book details the design and analysis of a 33KWp on-grid photovoltaic system that was monitored from January to December 2019. This report also looks at the design and performance of a 39.2KW grid-connected PV system on another building's block. The 39.2KW grid-connected system will be put on the fifth floor of a five-story structure. The grid-connected PV system with a capacity of 39.2KWp is proposed depending on the user's needs, and it includes three case studies for the same plant with varied orientations, including fixed tilt, seasonal tilt, and N-S axis tracking. Based on these case studies, the best tilt angle for PV plant construction can be determined. Different factors are used to analyse different case studies of field orientations. The performance of these off-grid photovoltaic systems is analysed and the performance parameters are measured over the course of a year. PVsyst, a simulation software, is used to analyse the data. For the three case studies, many metrics such as module efficiencies, inverter efficiencies, array initial yield, final array yield, and PV system performance ratio are examined.


Author(s) Details

Mortha Sai Veerraju
Professor, Dept. of Electrical & Electronics Engineering, S.R.K.R. Engineering College (A), Bhimavaram, India.

Yadavalli S. V. Venkateswara Rao
PG Scholar, Dept. of Electrical & Electronics Engineering, S.R.K.R. Engineering College (A), Bhimavaram, India.

View Book:- https://stm.bookpi.org/RSPVPPDAPS/article/view/2461

Let's Get Acquainted: Neuroleptic Cardiomyopathy | Book Publisher International

 The monograph covers a wide range of topics related to neuroleptic cardiomyopathy, which is induced by antipsychotic medications' cardiotoxic adverse effects.

For the first time, the disease's epidemiology, clinic, pathomorphology, pathogenesis, and diagnostic criteria are considered, and its nosological independence is justified. Myocardial hibernation in this pathology, as well as morphological changes in the heart in the comorbid course of various cardiomyopathies, are described.

The original author's method of organometry of the heart and the algorithm of morphometric study of the myocardium were used to conduct the morphological research. The final examination of the results was done using a variety of statistical methodologies.

With numerous tables and drawings, the book is well-illustrated. More than 700 sources are referenced in the bibliography.

The book is aimed towards researchers and practitioners working in the fields of general treatment, cardiology, and psychiatry, as well as experts who use antipsychotic medicines in their practise, medical educators, and students.

Author(s) Details

Volkov Vladimir Petrovich
Tver Regional Clinical Hospital, Russia.

View Book:- https://stm.bookpi.org/LGANC/article/view/2440

Friday, 30 July 2021

The Use of Stem and Root Barks Extracts from Synadenium glaucescens (Euphorbiaeceae) as Acid Base Indicators: Experimental Investigation | Chapter 16 | Technological Innovation in Pharmaceutical Research Vol. 8

 The use of industrially produced indicators, which are linked to environmental contamination, is currently required for the conduct of acid-base chemical interactions. This situation necessitates the search for other acid-base markers in natural sources. The goal of this study was to look at Synadenium glaucescens extracts' acid-base indicating capabilities. To look into S. Extracts from the leaves, stems, and root barks were evaluated for colour change, reversibility, pH range, and effectiveness during titration using strong and weak acids and bases to determine glaucescens' indicating capacity. Only the indicators derived from stem and root bark extracts were found to have indicating capacity, as they were able to change colour in response to pH changes. Both indicators had a pH range of 2.9 to 12.7, showing that they were more universal indicators. Both signs could be clearly inverted in acidity and alkalinity situations. The colour of the solution changed dramatically as the titration progressed. With their colour change from brick red to colourless and orange to colourless, the mean titre of the two indicators ranged from 24.3 0.31 to 25.4 0.75 and 18.9 0.17 to 24.1 0.05, respectively. The end points achieved by stem and root bark indicators correspond to the end points obtained by standard indicators such as phenolphthalein and methyl orange. As a result, acid-base indicators can be made from stem and root bark extracts. More research could be done to develop paper indicators and isolate the pure chemical that causes S. Signaling ability of Glaucescens


Author (s) Details

James G. Mayeka
Department of Education, Solomon Mahlangu College of Science and Education, Sokoine University of Agriculture, P. O. Box 3038, Morogoro, Tanzania.

Faith P. Mabiki
Department of Chemistry and Physics, Solomon Mahlangu College of Science and Education, Sokoine University of Agriculture P. O. Box 3038, Morogoro, Tanzania.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2219

Prescribing Pattern of Antimicrobial Agents in the Post-operative General Surgery Ward of a Tertiary Care Teaching Hospital: A Prospective Observational Study | Chapter 15 | Technological Innovation in Pharmaceutical Research Vol. 8

 Background: This prospective observational study was done to know the current prescription trend of antimicrobial agents in the post-operative ward. To evaluate the current pattern of antimicrobial agents in the post-operative surgical cases of a tertiary care teaching hospital.

The goal of this study was to look at the antimicrobial resistance pattern of culture isolates in post-operative general surgery cases. To evaluate the case for switching from one antimicrobial agent to another.

Methods: From April 2013 to March 2014, the study was conducted in conjunction with the Departments of General Surgery and Pharmacology. In the carefully built case proforma, all factors such as demographic data, antimicrobials agents given by surgeons, dose, frequency, duration, route, formulation, brand or generic medications, and adverse events were collected. SPSS version 17.0 was used to perform descriptive statistics.

Results: During the study period, 513 patient case records were analysed in which males are higher than females. A total of 816 drugs were used in 484 patients during the study period. 162 were on a single drug, 190 were on two drugs, 42 were on three drugs and 90 were on fixed dose combination. Brand name of the drugs and parenteral route of administration were preferred in the study. Cephalosporins (52.32 percent ) and metronidazole (34.38 percent ) were the most commonly prescribed group of antimicrobials followed by penicillin (0.9 percent ), aminoglycosides (6.58 percent ), quinolones (5.23 percent ), macrolides (0.45 percent ) and tetracycline (0.14 percent ). In all, 135 patients (27.89%) received pharmaceuticals that were not on the WHO's essential medicine list, while 112 patients (23.14%) received drugs that were not on the national EML.

Conclusions: Third-generation cephalosporins were the most commonly administered antibacterial medication in the post-operative ward. Antibiotics should be prescribed rationally to avoid polypharmacy and medication resistance. To support the appropriate use of medications in surgery, there is a definite need for the development of prescribing guidelines and educational programmes. Our research will aid clinicians in their understanding of the essential medicine list.

Author (s) Details

Velvizhy Ramalingam
Department of Pharmacology, Aarupadai Veedu Medical and Hospital, Pondicherry, India.

J. Johan Pandian
Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2218

Chlorpheniramine Maleate Pediatric Oral Strip: Methodology and Characterization | Chapter 14 | Technological Innovation in Pharmaceutical Research Vol. 8

 The purpose of this study is to develop an oral strip that is specifically intended for paediatric use and delivers a fast onset of action with ease of swallowing, especially for young people who have difficulties swallowing, as well as maximum therapeutic effectiveness by reducing the first pass effect.


Materials and methods: A solvent casting process was used to create the oral strip, which included a variety of sole polymers (hydroxypropyl methylcellulose [HPMC] 15cp, HPMC 50cp, polyvinyl alcohol, and sodium carboxymethyl cellulose). Three different plasticizers (propylene glycol, dibutyl phthalate, and glycerin) were used to improve the film forming polymer properties, and maltodextrin (MD) was used as the secondary polymer in varying ratios to optimise the release parameters and disintegration time (DT).

Results: It is clear from this study that F10, which is made up of HPMC as the main polymer and MD as the secondary polymer in a 2:1 ratio, provides adequate physicochemical characteristics, in-vitro/in-vivo DT (40/36 s), and a satisfactory release parameter of (59.9%) released at 2 min and (80%) released at 14.8 min.

Conclusion: The optimised formula appears to be promising for developing an oral strip that is simple to use, has a quick onset of action, and is well tolerated by children.

Author (s) Details

Sura Zuhair Mahmood
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Hiba Sabah Sabry
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Nora Zawar Yousif
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Zeina D. Salman
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2217

Radioprotective Agents in Radiotherapy: An Overview | Chapter 13 | Technological Innovation in Pharmaceutical Research Vol. 8

 Cancer stands as one of the most common causes for death of the individual worldwide. Radiotherapy is one of the treatment modalities in cancer where, exposure of the normal tissue to these ionising radiations, results in mutagenesis and cell death. Several modalities and clinical methods have been made to lessen these early and late problems of the radiotherapies and one of them is, by the means of pharmacological drugs. New notions of chemical and molecular pharmacological agents as radioprotective agents have emerged as a result of several experimental and clinical research. These have been utilised to avoid tissue damage from the radiations produced during the diagnostic and therapy phases of carcinomas. The clinical implications of these radioprotective compounds have emerged as promising drugs and with anti-tumour effect in the radiotherapy of various cancers, including oral carcinomas, to prevent the severe problems in irradiated patients.


Author (s) Details

Ugrappa Sridevi
AIMST Dental Institute, AIMST University, Semeling-Bedong, Kedah, Malaysia.

Ajay Jain
AIMST Dental Institute, AIMST University, Semeling-Bedong, Kedah, Malaysia.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2216

Nano Liposome: Tools for Target Drug Delivery | Chapter 12 | Technological Innovation in Pharmaceutical Research Vol. 8

 Liposomes are spherical artificial vesicles that can be made from natural phospholipids and cholesterol in nanoscale. Liposomes are spherical Micro- or Nano-sized particles with an interior water pool and a bilaminar membrane around them. Phospholipid molecules, or a mixture of phospholipids with sterols, such as cholesterol, or with other surface-active substances, are the membrane's building blocks. Liposomes are nanoscale spheroid vesicles with an aqueous core encased by one or more lipid bilayers. Thin-film hydration, reverse phase evaporation, and microfluidic mixing are all ways that can be used to make liposomes. Because of its interaction with corneocytes, the intracellular lipid, liposomal preparations diminish roughness, resulting in skin softening and smoothing. Liposome-based products are available for face and body care, make-up, mascara, and foundation, haircare, sunscreen products, and scents.


Author (s) Details

Biswaranjan Ray
Department of Pharmacology, CPS, Puri, Odisha, India.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2215

An Evaluation of Single Electron Transfer Reduction Products of 3-Oxoindoles as Antibacterial Agents | Chapter 11 | Technological Innovation in Pharmaceutical Research Vol. 8

 Antimicrobial resistance is rapidly spreading over the world as a result of widespread and indiscriminate antibiotic use. Reduction of indole derivatives is an important and fascinating topic of synthetic organic chemistry since it is used to make a variety of medicines, dyes, agrochemicals, and higher alkaloids.


The goal of this study is to evaluate the antibacterial properties of six indole derivatives, namely 3-(Naphth-1-y methyl) –indole (II), 3-(1-Naphthylcarbonyl – indole (III), 3,3' –diformyl-2,2' –bis indole (IV), 1,4- (3,3' –di indolyl) – 1.

Methods: The indole derivatives were synthesised from 3-formyl indole, which was further characterised by IR and NMR analyses. The antibacterial activity of the six produced compounds was tested using the agar diffusion method, and the results were validated using the microdilution technique to determine their MIC values.

Results: All of the compounds showed some activity against several bacterial species, with the exception of compound IV, which only showed activity against B. subtilis. Compound II was the most effective, with lower MIC values, against two Gram –ve and one Gram +ve bacteria, the Gram –ve bacteria being known to cause nosocomial and community-acquired illnesses.

Conclusion: Molecule II, as the most effective active compound, might be used as a starting point for further optimization, with the potential to contribute as a broad spectrum antibiotic.

Author (s) Details

Debasish Bandyopadhyay
Department of Chemistry, The University of Texas-Pan American, West University Drive, Edinburg, TX 78539, USA.

Irani Biswas
Department of Botany, The University of Burdwan, Burdwan 713104, W. Bengal, India.

Subrata Laskar
Department of Chemistry, The University of Burdwan, Burdwan - 713104, W.Bengal, India.

Bidyut Basak
Department of Chemistry, The University of Burdwan, Burdwan - 713104, W.Bengal, India.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2214

The Comparative Study Showing of the Effect of Telmisartan and Ramipril on Diabetic Profile in Hypertensive Pre-Diabetic Patients | Chapter 10 | Technological Innovation in Pharmaceutical Research Vol. 8

 Background: Hypertension, a prevalent cardiovascular disease, is rapidly being linked to other co-morbid disorders such as diabetes mellitus, which worsens its prognosis. Telmisartan and ramipril are both antihypertensive medications. The efficacy of telmisartan and ramipril in managing or avoiding the progression of pre-diabetes to diabetes in stage 1 hypertension patients is compared in this study. It also seeks to compare the effects of Telmisartan and Ramipril on FBS and HbA1C in males and females across a 12-month treatment period.


Methods: A 12-month prospective, randomised, single-center, comparative observational study on stage 1 hypertension patients with pre-diabetes is done. A total of 60 individuals are enlisted and assigned to one of two therapy groups. They were given the designated medicine for a 12-month period and were followed up on. Blood pressure was taken and a diabetes profile was checked at each appointment.

The results of this study demonstrated that both telmisartan and ramipril efficiently regulated blood pressure. In stage 1 hypertension individuals with pre diabetes, telmisartan reduced the progression of fasting blood sugar and glycosylated haemoglobin better than ramipril.

Conclusions: Both telmisartan and ramipril had an effect on blood pressure regulation. In stage 1 hypertension patients with pre diabetes, telmisartan has a statistically significant benefit in delaying the progression of prediabetes to diabetes mellitus when compared to ramipril.

Author (s) Details

Abdullah Ansari
Department of Pharmacology, Ayaan Institute of Medical Sciences, Moinabad, Telangana, India.

Ayesha Raoof
Department of Medicine, HAL Medical Centre, Hyderabad, Telangana, India.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2213

Study on Attitudes and Barriers of Medical Students towards Conducting Research in a Medical College | Chapter 9 | Technological Innovation in Pharmaceutical Research Vol. 8

 Background: Evidence-based medicine is well-known as the gold standard for clinical practise. Conducting thorough research can help with this. Medical students, as future doctors, should make a big contribution, however research among medical students is lacking in terms of presentations and publications.

The goal is to discover the many hurdles to undertaking research, as well as motivational factors and attitudes.

Methods: A semi-structured questionnaire was given to three different batches of medical students in this cross-sectional observational study.

The percentage of people who agreed to participate in research was only 30%. The total attitude and barrier score among them were 3.690.29 and 3.630.42, respectively, with statistical significance revealed between genders rather than batches. The most significant stumbling block was a lack of prior research experience (91.67 percent ). Self-interest was the most common source of motivation (90.7 percent ).

Conclusions: If medical students are given adequate training and facilities, they should be able to conduct more research.

Author (s) Details

Manjunath G. Narasimhaiah
Department of Pharmacology, Sri Siddhartha Medical College, Tumkur, Karnataka, India.

Swamy R. Mallikarjuna
Department of Pharmacology, Sri Siddhartha Medical College, Tumkur, Karnataka, India.

Riyaj A. Kalaburgi
Department of Community Medicine, Sri Siddhartha Medical College, Tumkur, Karnataka, India.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2212

Morbidity and Drug Utilization Pattern among Pregnant Admitted Anemic Women and to Find Out Rationality of Drug by Using Indian Guidelines | Chapter 8 | Technological Innovation in Pharmaceutical Research Vol. 8

 Background: Pregnancy is a unique physiological state during which drug use is increasingly frowned upon due to the potential of teratogenicity. Anemia is a common cause of death in mothers. As a result, our goal was to look into drug usage, teratogenic risk, and prescription rationality among pregnant anaemia patients.

Materials and Methods: A prospective observational research was conducted in 150 indoor patients at a tertiary care hospital. The Institutional Review Board gave their approval to the protocol (IRB). The information was gathered using a pre-designed proforma. SPSS version 20.0 software was used to analyse the data.

The results showed that out of 150 patients, 23, 111, and 16 were under 20, 20 to 30, and over 30 years old, respectively. Pregnancy-induced hypertension (18.7%) and antepartum haemorrhage (12.7%) were prevalent among anaemic individuals. Around 71 percent of women report feeling weak, followed by a headache. The most commonly recommended medicines were iron (93.3%) and calcium (86.0%). In severe anaemia, iron sucrose and packed cell volume are administered. The most commonly prescribed drug risk category was Category-A (90.21 percent), followed by Category-B (8.0 percent) and Category-C (4.0 percent) (1.8 percent ). 70.3 and 89.2% of medications were prescribed by generic name and from the essential drug list, respectively. According to Indian guidelines, the overall prescribing behaviour was logical.

Conclusion: In anaemic individuals, the most usually prescribed medicines were iron, calcium, and folic acid. During drug use, no teratogenic risk was discovered. The medicine and its dosage were both reasonable and adequate. The number of medications prescribed under generic name is lower, as is hospital supply.

Author (s) Details

Harsh M. Joshi
Department of Pharmacology, N.H.L. Municipal Medical College, Ahmadabad, Gujarat, India.

Jayun M. Joshi
Department of Obstetrics and Gynecology, L.G. Hospital, Ahmedabad, Gujarat, India.

Kamlesh P. Patel
Department of Pharmacology, N.H.L. Municipal Medical College, Ahmadabad, Gujarat, India.

Kartik N. Shah
Department of Pharmacology, N.H.L. Municipal Medical College, Ahmadabad, Gujarat, India.

Varsha J. Patel
Department of Pharmacology, Dr. M.K. Shah Medical Collage & Research Centre, Ahmadabad, Gujarat, India.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2211