Prognostic Factors and Postoperative Survival in Clear Cell Renal Carcinomas. A Histopathological Diagnosis| Chapter 2 | Highlights on Medicine and Medical Science Vol. 9

 Introduction: a cell that is clear The most prevalent kind of Renal Cell Carcinoma that arises in adulthood is ccRCC, which has the worst prognosis among the major epithelial cancers of these organs. A high blood supply characterises this neoplasm. In light of this, we used CD34, an endothelial antigen that has previously been used to highlight microvessel density (MVD), as a direct marker of neoangiogenesis degree. The goal of this study was to see if there was a link between CD34 and other prognostic indicators such Fuhrman nuclear degree and tumour size. Material and Methods: Tumour tissues from 17 individuals with a histopathological diagnosis of ccRCC were stained for CD34 using immunohistochemistry. Anova and Student Newman Multiple Comparison Test with Tuckey as a post-test were used to examine CD34 expression, and then we utilised a Spearman Correlation to compare it to the other prognostic markers studied, as well as Kaplan Meier survival analysis for the patients' disease-free survival. The MVD has a negative association with the Fuhrman nuclear grade, with R = -0,46 and p = 0,05, and a positive correlation with the maximum tumour diameter, with R = 0,47 and p = 0,05. Finally, we discovered that a high MVD is associated with a low Fuhrman nuclear grade and a large tumour size. The relevance of this research could be that we require more than one parameter to predict the ccCCR's biological behaviour.

Author(s) Details

P. Colaci
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina and Hospital Zonal General de Agudos “Evita Pueblo”, Berazategui, Bs. As., Argentina.

A. L. Errecalde
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.

A. M. Inda
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.

M. Garcia
Cátedra de Citología, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina.


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