Experimental Studies on Efficacy of Dexmeditomidine and Magnesium as Adjuncts to Epidural Bupivacaine for Upper Abdominal Surgeries | Chapter 1 | Technological Innovation in Pharmaceutical Research Vol. 8

 The purpose of this prospective, randomised, double-blind study was to evaluate if adding magnesium or dexmedetomidine to epidural bupivacaine in upper abdominal surgeries influenced the result.

Materials and Methods: Sixty ASA (American Society of Anesthesiologists) class I and II patients were randomly randomised to magnesium sulphate (Group M) or dexmedetomidine (Group D) as well as epidural bupivacaine for surgical anaesthetic during upper abdominal procedures. An epidural anaesthetic with 8 ml of 0.5 percent bupivacaine and either 50 mg MgSO4 (Group M) or 1 g/kg dexmedetomidine was given to all study participants (Group D). The duration of analgesia, the total amount of rescue analgesic required, hemodynamic parameters, and any adverse events were all kept track of.

The requirement for rescue analgesics was lower in Group BD, as was analgesia in the postoperative phase. In Group BD, sedation was more common.

Dexmeditomidine extends the duration of analgesia while also causing considerable drowsiness. As a result, combining dexemedetomidine with epidural bupivacaine could result in increased analgesia and arousable sedation.

Author (s) Details

Tantry Tariq Gani
Department of Anaesthesiology and Critical Care, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Abdul Waheed Mir
Department of Anaesthesiology and Critical Care, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Mohamad Akbar Shah
Department of Anaesthesiology and Critical Care, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Farooq Ahmad Ganie
Department of Cardio Vascular and Thoracic Surgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Shazia Naz
Department of Anaesthesiology and Critical Care, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Mohd Iqbal Dar
Department of Cardiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

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