Studies on Increased Prevalence of Hernia, Uterine Descent, Fibrous Adhesions, Retroperitoneal Fibrosis and Germ Cells with Endogenous Estrogen | Chapter 11 | Highlights on Medicine and Medical Science Vol. 8

 Background: Increased prevalence of hernias, uterine descent, fibrous adhesions manifesting as colic abdominal pain, retroperitoneal fibrosis, intestinal obstruction, and volvulus were observed during the era of contraception and abortions [20th, 21st century] adopted as family welfare schemes.

The researchers wanted to see if there was an altruistic link between contraception and increased hernias, uterine descent, fibrous adhesions advancing to retroperitoneal fibrosis, volvulus, and intestinal obstructions.

Methods: In 2012, a retrospective analysis of the prevalence of hernia, uterine descent, in 350 patients aged 20-35 years, 35-50 years, and >50 years, from data collected by convenient, stratified random sampling, from various geographical locations, between 2003 and 2012, and its association with the presence, absence, and abortion was carried out; concurrently, serum oestrogen levels were measured.

Between 2000 and 2012, 25 individuals were found to have fibrous adhesions, related intestinal obstruction, volvulus, and retroperitoneal fibrosis in clinical practise; they were evaluated to see if there was a link between contraception, hysterectomy, and a cholesterol-restricted diet.

Results: With a p value of 0.0025 in 20-35 years, p value of 0.0005 in 35-50 years, and p value of 0.02 in >50 years, there was a 3-6 fold increase in hernia in contraceptive users aged >20 to >50 years: Fig. 2.

With a p value of 0.0005, there was an 8- 9 fold increase in the prevalence of fibrous adhesions in contraception users aged 20 to 50 years, and a 2 fold rise in retroperitoneal fibrosis and volvulus in those taking contraception and following hysterectomy with a p value of 0.025: Figure 1

In 61 percent of contraceptive users, endogenous oestrogen levels were below normal, and 25% of contraceptive users had low normal serum oestrogen levels with a p value of 0.0005: Figure 3: A low-cholesterol diet was linked to a 50 percent rise in degenerative illnesses, including volvulus with fibrous adhesions, leading to decreased synthesis of endogenous oestrogen androgen.

Conclusion: The concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous oestrogen: androgen, resulting in defaulted genomic repertoire, deranged cell cycle, cell metabolism, and increased degenerative pathologies such as hernia, uterine descent, and fibrous adhesions progressing to volvulus, retroperitoneal fibrosis, intestinal obstruction, and mesenteric fibrosis.

Corrective operations combined with tubal recanalisation: contraceptive reversal was achieved without recurrence or problems by restoration of genetic repertoire-figure supplemental file

Author (s) Details

Elizabeth JeyaVardhini Samuel
Karpagam Faculty of Medical Sciences and Research, Madras University, Tamilnadu, India.

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