Methylation of a hydroxy group eliminates or reduces that group's ability to create hydrogen bonds. The action is amplified when a hydroxy group is converted to a methylene (deoxy) group. S-adenosyl-methionine is the most common methyl donor in living creatures' cells (Ado-Met). N5,N10-THFA or a cobalt atom of a corrin ring can sometimes contribute a methyl group. Despite the limited number of natural methyl donors (in comparison to phosphate donors), partly reduced or methylated sugars have been discovered in glycosterols, polysaccharides, and other compounds. Nucleoside-type glycosides, glycosphingolipids, gangliosides, antigenic phenolic glycolipids, inositols Nucleic acids are methylated mostly on cytosine and adenine, while proteins are methylated on Glu and Asp.
Author (s) Details
Dumitru Petru I. Iga
University of Bucharest, former C. I. Parhon, Bucharest, Rumania and University of Oradea, B-dul Armata Romana, Oradea, Nagyvárad, Rumania.
Dumitru Popescu
Gh. Mihoc-Caius Iacob Institute of Mathematical Statistics and Applied Mathematics of Romania Academy, 13 Calea 13 Septembrie, 050711, Bucharest, Romania.
Valentin I. R. Niculescu
Institut de Recherche et Development pour les Lasers, Plasma et Physique de la Radiation, Magurele-Bucharest, Romania.
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