Nannochloropsis gaditana as a Source of Novel Antitumor Compounds | Chapter 8 | Recent Research Advances in Biology Vol. 10

 Proteomics techniques have evolved over the last few decades into a critical tool for understanding the dynamics of proteins in biological processes, as well as an important methodology for academic and practical research [1-4]. To organise and understand the massive amount of data generated by a single proteomics experiment, a variety of bioinformatic tools are necessary. By comparing the retrieved protein information with the existing patents database, a unique approach called "Applied Proteomics" has been created to get insight into prospective uses of the identified proteins. The application of proteome of non-model microorganisms, which have been extensively characterised as a novel source of metabolites [5-8], has been enabled by the advent of large sequencing technology and MS/MS advances. Nannochloropsis gaditana has been identified as a potential alternative source of biomolecules [9-13]. Our research group recently published the first full proteome analysis of this microalga [14], which identified 488 proteins with potential commercial applications utilising the applied proteomics paradigm. To test our method, we used the protein UCA01 from the prohibitin family. In conclusion, the revalorization of microalgae biomass is a critical element in the European Union's "Blue Growth" politicies. UCA01, a protein derived from Nannochloropsis gaditana, has been created as a new cancer-fighting weapon. This protein has a specific inhibitory effect on tumour cell proliferation while having no effect on control cells. This concept, dubbed "applied proteomics," provides the first practical approach to transforming proteome information in a prospective commercial application. It is based on a revolutionary bio-algorithm that can identify proteins that have potential industrial applications. Hundreds of proteins have been described.

Author (s) Details

Carrasco-Reinado, Rafael
Microbiology Laboratory, Institute of Viticulture and Agri-food Research (IVAGRO), University of Cádiz, Pol. Río San Pedro s/n, Puerto Real, Cádiz, Spain.

Escobar-Niño, Almudena
Microbiology Laboratory, Institute of Viticulture and Agri-food Research (IVAGRO), University of Cádiz, Pol. Río San Pedro s/n, Puerto Real, Cádiz, Spain.

Fernández-Acero, Francisco Javier
Microbiology Laboratory, Institute of Viticulture and Agri-food Research (IVAGRO), University of Cádiz, Pol. Río San Pedro s/n, Puerto Real, Cádiz, Spain.

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