Chlorpheniramine Maleate Pediatric Oral Strip: Methodology and Characterization | Chapter 14 | Technological Innovation in Pharmaceutical Research Vol. 8

 The purpose of this study is to develop an oral strip that is specifically intended for paediatric use and delivers a fast onset of action with ease of swallowing, especially for young people who have difficulties swallowing, as well as maximum therapeutic effectiveness by reducing the first pass effect.

Materials and methods: A solvent casting process was used to create the oral strip, which included a variety of sole polymers (hydroxypropyl methylcellulose [HPMC] 15cp, HPMC 50cp, polyvinyl alcohol, and sodium carboxymethyl cellulose). Three different plasticizers (propylene glycol, dibutyl phthalate, and glycerin) were used to improve the film forming polymer properties, and maltodextrin (MD) was used as the secondary polymer in varying ratios to optimise the release parameters and disintegration time (DT).

Results: It is clear from this study that F10, which is made up of HPMC as the main polymer and MD as the secondary polymer in a 2:1 ratio, provides adequate physicochemical characteristics, in-vitro/in-vivo DT (40/36 s), and a satisfactory release parameter of (59.9%) released at 2 min and (80%) released at 14.8 min.

Conclusion: The optimised formula appears to be promising for developing an oral strip that is simple to use, has a quick onset of action, and is well tolerated by children.

Author (s) Details

Sura Zuhair Mahmood
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Hiba Sabah Sabry
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Nora Zawar Yousif
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Zeina D. Salman
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

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