Fabrication of hybrid hydrogels to improve biological characteristics or mitigate biomaterial drawbacks has become a prominent method. With the growing threat of skin wounds to public health and the economy, this study was conducted using xanthan gum (Xnt), citric acid (C), gelatin (Gel), glutaraldehyde (G), and HPLC-grade water to fabricate a series of composite hydrogels, including Xnt, Xnt:C, Xnt:Gel(3):G, Xnt:C:Gel(3):G, X All of the composite hydrogels comprised more than 90% water, according to physicochemical analysis. Swelling ability, biodegradability, excellent polymeric networks, and porosity were all demonstrated in the hydrogels. The existence of bound water and free, intra and inter molecule bound hydrogen linked OH and NH in the hydrogels was confirmed using Fourier Transform Infrared Spectroscopy (FT-IR). When compared to controls, all of the hydrogels showed considerable wound healing power in experimental deep second-degree skin burns in rats. Xnt:Gel(3):G, Xnt:Gel(5):G, and Xnt:C:Gel(5):G-treated wounds recovered faster than those treated with other composite hydrogels 20 days after application. The presence of Gel in the formulations may account for the maximum wound contraction of these hydrogel composites. Xnt:Gel(3):G, Xnt:Gel(5):G, and Xnt:C:Gel(5):G may be useful wound dressing materials, according to our findings.
Author (s) Details
Mohammad Mahfuz Ali Khan Shawan
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Nazmul Islam
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Shahin Aziz
BCSIR Laboratories, Council of Scientific and Industrial Research, Mirpur Road, Dhaka-1205, Bangladesh.
Nazia Khatun
BCSIR Laboratories, Council of Scientific and Industrial Research, Mirpur Road, Dhaka-1205, Bangladesh.
Satya Ranjan Sarker
Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Mozammel Hossain
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Tareq Hossan
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Mahbubul Morshed
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Marzan Sarkar
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Md. Salman Shakil
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Md. Nazibur Rahman
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Most. Hosney Ara Begum
BCSIR Laboratories, Council of Scientific and Industrial Research, Mirpur Road, Dhaka-1205, Bangladesh.
Md. Ashraful Hasan
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
View Book :- https://stm.bookpi.org/CACB-V9/article/view/2203
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