NSAIDs (non-steroidal anti-inflammatory medicines) such as ibuprofen were intercalated in-situ into the interlayer gap of Mg Al LDH nanoparticles during the co-precipitation of hydroxides in the current study. LDHs are made up of a water molecule and a positive charge compensating and exchangeable anion. XRD, FTIR, and UV spectroscopy were used to characterise LDH nanohybrids. Co-precipitation was used to make Mg1-xAlx(NO3)x(OH)2.nH2O nanoparticles from an aqueous solution of Mg(NO3)2.6H2O and Al(NO3)3.9H2O. During the coprecipitation of the drug LDH conjugate in nitrogen, ibuprofen was intercalated in the interlayer gap of Mg-Al LDH. atmosphere. The nanopowders produced ranged in size from 25 to 90 nm, with an average particle size of 55 nm. Due to the intercalation of larger ibuprofen molecules in the interlayer space of LDH, XRD examination revealed a rise in d003 spacing from 7.89 for pure LDH to 14.71 for ibuprofen intercalated LDH. The intercalation of ibuprofen in the interlayer structure of LDH was confirmed by FTIR analysis, which revealed hydroxyl and carbonyl stretching of ibuprofen in the LDH-IBU sample. Using UV-Vis spectroscopy, a study of drug release kinetics in phosphate buffer solution at pH 7.4 revealed that 50% of drug molecules were released after 15 hours and more than 85% were released within 24 hours.
Author (s) Details
Dr. Sudip Dasgupta
Department of Ceramic Engineering, National Institute of Technology, Rourkela, Odisha 769008, India.
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