Enhancement of Solubility and Dissolution Rate of Ibuprofen: A Factorial Study Approach | Chapter 1 | Advanced Concepts in Pharmaceutical Research Vol. 5

This chapter highlights about enhancing the solubility and dissolution rate of ibuprofen by the use of β cyclodextrin ( βCD) and Solutol HS15. Ibuprofen (IBP) is a nonsteroidal antiinflammatory drug (NSAID) derived from propionic acid and used widely as an analgesic and antipyretic; although it is also used for relief from symptoms of rheumatoid arthritis and osteoarthritis in addition to treatment of dysmenorrhoea, amongst other indications. An UV Spectrophotometric method based on the measurement of absorbance at 221 nm in phosphate buffer pH 7.2 was used for the estimation of ibuprofen. The individual main effects and combined (or interaction) effect of βCD (Factor A) and Solutol HS15 (Factor B) in enhancing the solubility and dissolution rate of ibuprofen were evaluated in a 22 factorial study. The individual and combined effects of βCD and Solutol HS15 in enhancing the solubility of ibuprofen were highly significant (P < 0.01). βCD and Solutol HS15 alone gave respectively 12.83 and 42.32 fold increase in the solubility of ibuprofen. Combination of βCD with Solutol HS15 resulted in a much higher enhancement in the solubility of ibuprofen, 55.78 fold. When it came to increasing the dissolution rate (K1) and dissolving efficiency (DE30), the main and combination (interaction) effects of CD (Factor A) and Solutol HS15 (Factor B) were extremely significant (P 0.01). βCD and Solutol HS15 alone gave respectively 7.78 and 19.41 fold increase in the dissolution rate of (K1) of ibuprofen and in combination they gave a 27.11 fold increase in the dissolution rate (K1) of ibuprofen. Ibuprofen's ability to dissolve more quickly when Solutol HS15 and CD are combined than when they are used alone. Ibuprofen's dissolving rate was increased by 19.41 fold, and its dissolution efficiency increased by 3.23 fold, when solutol HS15 was used alone. In order to improve the solubility, dissolution rate, and dissolution efficiency of ibuprofen, a weakly soluble BCS class II medication, a combination of CD and Solutol HS15 or Solutol HS15 alone is advised.

Author(s) Details:

K. P. R. Chowdary,
AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

G. S. Annamma Devi,
AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

K. Susmitha,
AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13241

Inadvertent Intravenous Administration of an Oral Preparation of Ibuprofen: A Case Report | Chapter 4 | Current Practice in Medical Science Vol. 5

 

 Accidental intravenous delivery of oral suspension, which is rarely addressed in standard practice, may result in patient injury. We were given a report of an instance where a patient had unintentionally taken an oral liquid formulation intravenously. The main reason for this inaccuracy is the custom of preparing or administering oral liquids in parenteral syringes. The attachability of parenteral syringes to needleless IV lines via the Luer connection as well as the cognitive weariness staff members experience when multitasking are other factors that contribute to the incidence. Healthcare professionals tend to downplay this fact, thus we constantly educate our employees to dispense and provide unit dosages of oral liquids using oral syringes. As a result, oral preparations that are commercially available or custom-made should be administered using specific cups, oral syringes, or other containers that are appropriate for the particular preparation. Oral syringes must be accessible in the hospital and in patient areas where liquid doses are given orally in order to ensure compliance with this practice. Since oral syringes are not readily available in Pakistan, nurses frequently administer oral liquids using intravenous syringes to prevent dose spillage, particularly in toddlers or uncooperative patients. The availability of oral syringes in hospitals may aid in reducing medication errors during accidental administration.

Author(s) Details:

Muhammad Gulzaib,
Department of Pharmacy Services, Shifa International Hospitals Ltd. (SIH), Pitras Bukhari Road, H-8/4, Islamabad, Pakistan.

Salwa Ahsan,
Department of Pharmacy Services, Shifa International Hospitals Ltd. (SIH), Pitras Bukhari Road, H-8/4, Islamabad, Pakistan.

Yawar Najam,
Department of Pediatrics, Shifa International Hospitals Ltd. (SIH), Pitras Bukhari Road, H-8/4, Islamabad, Pakistan.

Please see the link here: https://stm.bookpi.org/CPMS-V5/article/view/7652

Study of Controlled Release of Ibuprofen Using Mg Al LDH Nano Carrier | Chapter 9 | New Approaches in Engineering Research Vol. 7

 NSAIDs (non-steroidal anti-inflammatory medicines) such as ibuprofen were intercalated in-situ into the interlayer gap of Mg Al LDH nanoparticles during the co-precipitation of hydroxides in the current study. LDHs are made up of a water molecule and a positive charge compensating and exchangeable anion. XRD, FTIR, and UV spectroscopy were used to characterise LDH nanohybrids. Co-precipitation was used to make Mg1-xAlx(NO3)x(OH)2.nH2O nanoparticles from an aqueous solution of Mg(NO3)2.6H2O and Al(NO3)3.9H2O. During the coprecipitation of the drug LDH conjugate in nitrogen, ibuprofen was intercalated in the interlayer gap of Mg-Al LDH. atmosphere. The nanopowders produced ranged in size from 25 to 90 nm, with an average particle size of 55 nm. Due to the intercalation of larger ibuprofen molecules in the interlayer space of LDH, XRD examination revealed a rise in d003 spacing from 7.89 for pure LDH to 14.71 for ibuprofen intercalated LDH. The intercalation of ibuprofen in the interlayer structure of LDH was confirmed by FTIR analysis, which revealed hydroxyl and carbonyl stretching of ibuprofen in the LDH-IBU sample. Using UV-Vis spectroscopy, a study of drug release kinetics in phosphate buffer solution at pH 7.4 revealed that 50% of drug molecules were released after 15 hours and more than 85% were released within 24 hours.

Author (s) Details

Dr. Sudip Dasgupta
Department of Ceramic Engineering, National Institute of Technology, Rourkela, Odisha 769008, India.

View Book :- https://stm.bookpi.org/NAER-V7/article/view/2228

A Narrative Review on the Effect of Acetaminophen and Ibuprofen in Orthodontic Tooth Movement | Chapter 14 | Challenges in Disease and Health Research Vol. 4

 Application of orthodontic force causes an inflammatory event resulting in bone resorption and subsequent orthodontic tooth movement (OTM) in the periodontium. The release of inflammatory mediators such as E2 prostaglandins and Interleukin-1β serve as potent bone resorption stimulators. Strong force application results in discomfort and the same non-steroidal anti-inflammatory medications (NSAIDs) are recommended for relief. By interfering with prostaglandin (PG) synthesis, these NSAIDs negate the inflammatory reactions, thereby inhibiting orthodontic tooth movement. The aim of this mini literature review was to highlight the impact on their pain relieving capacity and effect on OTM of the two widely used medications, namely acetaminophen and ibuprofen. It was concluded that acetaminophen was a potent analgesic that could be used to alleviate orthodontic treatment-related pain because its effect was at the level of the central nervous system and not at the cell level. The degree of the membrane as well as its inhibitory effect on OTM was not a matter of concern as it inhibited the PG synthesis only slightly. Ibuprofen, on the other hand, acted as a mild analgesic and, with its anti-inflammatory effect, also inhibited OTM. At the peripheral stage, ibuprofen reduces PGs, thereby influencing osteoclastic activity and the subsequent deceleration of orthodontic tooth movement. Instead of ibuprofen, acetaminophen is the recommended medication of choice for reliving pain and discomfort during orthodontic therapy.

Author (s) Details

Dr. A. Arif Yezdani
Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.


Dr. Mansi Giri
Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/287