The qualities of the active pharmaceutical ingredient (API) as well as the features of the dosage form influence the rate and degree of medication dissolution and absorption. The dissolving patterns of furosemide tablets from nine commercially available products in Argentina were investigated in this study. All of the brands meet the USP dissolution test requirements. Model-dependent and model-independent techniques were used to compare dissolution profiles. The optimum kinetic curve adjustment came from the Weibull model. The most fitting brands were IV, VI, and IX, which had the highest determination coefficient and the least AIC values. The results of the model-independent approach revealed that there was no significant difference in Dissolution efficiency or Mean dissolution time between the reference product and Brands II, III, IV, and V. Only Brands I and III were equivalent in terms of fit factors. In vivo bioequivalence of furosemide market goods has been proven, and interchangeability with generics should be avoided.
Author (s) Details
Yong K. Han
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.
Laura D. Simionato
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.
Romina G. Calvo
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.
María B. Mattei
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.
Adriana I. Segall
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.
View Book :- https://stm.bookpi.org/CACB-V9/article/view/2200
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