The Influence of Amiodarone Complexation with 2-Hydroxypropyl- β -Cyclodextrin in Oral Matrix Tablets Delivery: In vitro and In vivo Evaluation | Chapter 2 | Progress in Chemical Science Research Vol. 9

 The present work is engaging attention the new synthesized and distinguished three component ion-exchanger. Inorganic cation-exchanger have drawn the attention to their discrimination, temperature, warm and chemical stabilities. The most warm and chemical properties concerning this material is prepared by intermixing answers of sodium molybdate (0.1 M), sodium arsenate (0.1 M) and antimony(III) chloride (0.1 M) solution indifferent volume percentages at pH-1. All of the samples' Ion-exchange capacities were assessed utilizing a column method. For in-depth reasonings, the chosen sample was synthesised in large quantities. Its ion-exchange competency of synthesized material for Na+ has happened found expected 2.30 meq/g. The loss of weight and change in colour of the ion-exchanger was noticed in each case and ion-exchange capacity was contingent upon column arrangement. Antimony(III) molybdoarsenate is good ion-exchange capacity and is resistant up to a fairly extreme heat, and fairly resistant in different sour, basic and organic news. The prepared material was characterised utilizing a variety of limits, including FTIR, TGA curve, X-ray dissemination, pH titration, Kd values, thermal & synthetic stabilities, and other studies. The attained binary and water softening separations for differing analytical practical uses have dressed as a demonstration of the synthesised ion- exchanger.

Author(s) Details:

Andreea Creteanu,
Department of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16th Universitatii St., 700115, Iasi, Romania.

Daniela Pamfil,
Physical Chemistry of Polymers Department, Petru Poni Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, RO700487, Iasi, Romania.

Cornelia Vasile,
Physical Chemistry of Polymers Department, Petru Poni Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, RO700487, Iasi, Romania.

Alina Ghilan,
Physical Chemistry of Polymers Department, Petru Poni Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, RO700487, Iasi, Romania.

Gladiola Tantaru,
Department of Analytical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16th University St., 700115, Iasi, Romania.

Please see the link here: https://stm.bookpi.org/PCSR-V9/article/view/10696

The Influence of Amiodarone Complexation with 2-Hydroxypropyl- β -Cyclodextrin in Oral Matrix Tablets Delivery: In vitro and In vivo Evaluation | Chapter 2 | Progress in Chemical Science Research Vol. 9

 The aims of this study were to improve both the solubility of the amiodarone hydrochloride (AMD) and its controlled release from the inclusion complexes with 2-hydroxypropyl- β-cyclodextrin (HP- β-CD).The complexation with cyclodextrins (CDs) is a method to optimize the therapeutic performance of the insoluble drugs, including AMD. The inclusion complexes were prepared by co-precipitation and freeze-drying. The solubility enhancement of AMD/HP- β-CD inclusion complexes increase by 4–22 times was evaluated by the phase solubility method. The inclusion complexes were studied both in solution and in solid state by spectroscopic methods, dynamic light scattering (DLS), zeta-potential (ZP) analysis, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC).

The obtained inclusion complexes (AMD/HP- β-CD) showed an increase in solubility by more than 200%.

Two kinds of formulations have been tested namely of AMD/HP- β-CD inclusion complexes both as powdered form and as matrix tablets containing Kollidon®SR (KOL), Chitosan (CHT) and one containing only pure AMD as a control sample. The kinetics of AMD release form the two kinds of formulations was evaluated by in vitro and in vivo studies. The active substance release was followed by in vitro release testing and the results were analyzed by fitting into four representative mathematical models for the modified release oral formulations. The release of the active substance from the matrix modified tablets is dependent on its solubility degree in the dissolution medium as well as on the composition of the matrix forming polymers. It was found that both formulations showed superior pharmacokinetic performance by improving both loading and release properties in respect with those of the pure low soluble AMD drug.

In vitro kinetic study reveals a complex mechanism of release which occurred in three steps, the first one is attributed to a burst effect and the other two to different bondings existing in inclusion complexes. Two factors have been calculated to assess the release profile of amiodarone: f1 - the similarity factor and f2 - the difference factor. Akaike index and the correlation coefficient were the criteria used for selecting the model that most faithfully depicted the release profile of each studied formulation.

In vivo tests on complexed aminodarone loaded in matrix tablets containing KOL and CHT revealed a multiple (at least two) peaks release diagram because of both structure of the inclusion complexes and also of different sites of absorption in biological media (digestive tract).

Author(s) Details:

Andreea Creteanu,
Department of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16th Universitatii St., 700115, Iasi, Romania.

Daniela Pamfil,
Physical Chemistry of Polymers Department, Petru Poni Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, RO700487, Iasi, Romania.

Cornelia Vasile,
Physical Chemistry of Polymers Department, Petru Poni Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, RO700487, Iasi, Romania.

Alina Ghilan,
Physical Chemistry of Polymers Department, Petru Poni Institute of Macromolecular Chemistry, 41A Gr. Ghica Voda Alley, RO700487, Iasi, Romania.

Gladiola Tantaru,
Department of Analytical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16th University St., 700115, Iasi, Romania.

Please see the link here: https://stm.bookpi.org/PCSR-V9/article/view/10696

Study on Formulation and Evaluation of Famotidine Tablets Prepared by Using Guava Starch as Binding Agents | Chapter 7 | Current Aspects in Pharmaceutical Research and Development Vol. 5

 The release of a medicine is affected by the excipients employed in its formulation. In the case of tablets, binders play a key role in drug release. As a result, the following study uses natural excipients to try to improve a drug's solubility and dissolving rate (Guava Starch).

Methods: Because the unripe fruit of the guava has a large amount of starch, it can be utilised to extract starch. The extracted starch was then tested and shown to be effective as a binder in famotidine pills at varied concentrations. The tablets were made with guava starch concentrations of 2 percent w/v, 4 percent w/v, 6 percent w/v, and 8 percent w/v via a wet granulation technique. The weight variation, hardness, friability, disintegration time, and in-vitro drug release of the prepared famotidine tablets were then investigated.

The resulting starch is comparable to standard starch in terms of both quality and quantity. As the starch concentration was increased, the tablets' hardness and disintegration time increased. Tablets with the highest binder concentration had the highest hardness (6.0 kg) and disintegration time (8.0 min), as well as the lowest friability (0.76 percent ). Tablets containing 4% w/v starch showed the largest drug release after one hour (83.54 percent).

Conclusion: Guava starch has strong binding characteristics, according to the results of numerous studies. As a result, it can be utilised as a tablet binder in medicinal formulations.

Author(S) Details

Kushwaha Anjali
School of Pharmacy, BBD University, Lucknow, India.

Singh P. Manjul
School of Pharmacy, BBD University, Lucknow, India.

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Development of High Performance Liquid Chromatographic Determination of Ambroxol, Roxithromycin and Serratiopeptidase in Combined Tablet Dosage Forms | Chapter 6 | New Innovations in Chemistry and Biochemistry Vol. 3

 The researchers devised and validated a simple, sensitive, and accurate RP-HPLC technique for the simultaneous measurement of ambroxol, roxithromycin, and serratiopeptidase in bulk and combination tablet dose form. Using a Waters HPLC system with a YMC Pack pro C18 (250 4.6 mm, 5 m particle size) column, ambroxol, roxithromycin, and serratiopeptidase were separated and quantified. The mobile phase was made up of 0.1 percent orthophosphoric acid and 60:40 v/v acetonitrile. The calibration curves for ambroxol, roxithromycin, and serratiopeptidase were linear over concentration ranges of 12-36 g/mL, 60-180 g/mL, and 6-18 g/mL, with limits of detection of 0.040 g/mL, 1.176 g/mL, and 0.127 g/mL, respectively. Recovery rates ranged from 99.57 percent to 100.24 percent for the medications tested, with relative standard deviations ranging from 0.12 percent to 0.36 percent. According to the ICH criteria, the devised approach was validated. The proposed RP-HPLC method might be utilised to analyse ambroxol, roxithromycin, and serratiopeptidase in combination tablet dosage forms at the same time.

Author(S) Details

G. Sailaja
Department of Chemistry, Singareni Collieries Women’s Degree College, Kothagudem, Khammam, Andhra Pradesh, India.

P. R. K. Veni
Department of Chemistry, Sasi Institute of Technology and Engineering, Tadepalligudem, W.G. Dist., AP, India.

B. Hari Babu
Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

View Book:- https://stm.bookpi.org/NICB-V3/article/view/4010

A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2) | Chapter 9 | Current Advances in Chemistry and Biochemistry Vol. 9

 The qualities of the active pharmaceutical ingredient (API) as well as the features of the dosage form influence the rate and degree of medication dissolution and absorption. The dissolving patterns of furosemide tablets from nine commercially available products in Argentina were investigated in this study. All of the brands meet the USP dissolution test requirements. Model-dependent and model-independent techniques were used to compare dissolution profiles. The optimum kinetic curve adjustment came from the Weibull model. The most fitting brands were IV, VI, and IX, which had the highest determination coefficient and the least AIC values. The results of the model-independent approach revealed that there was no significant difference in Dissolution efficiency or Mean dissolution time between the reference product and Brands II, III, IV, and V. Only Brands I and III were equivalent in terms of fit factors. In vivo bioequivalence of furosemide market goods has been proven, and interchangeability with generics should be avoided.

Author (s) Details

Yong K. Han
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.

Laura D. Simionato
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.

Romina G. Calvo
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.

María B. Mattei
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.

Adriana I. Segall
Cátedra de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, CONICET, Junín 956 (1113) CABA, Argentina.

View Book :- https://stm.bookpi.org/CACB-V9/article/view/2200