The release of a medicine is affected by the excipients employed in its formulation. In the case of tablets, binders play a key role in drug release. As a result, the following study uses natural excipients to try to improve a drug's solubility and dissolving rate (Guava Starch).
Methods: Because the unripe fruit of the guava has a large amount of starch, it can be utilised to extract starch. The extracted starch was then tested and shown to be effective as a binder in famotidine pills at varied concentrations. The tablets were made with guava starch concentrations of 2 percent w/v, 4 percent w/v, 6 percent w/v, and 8 percent w/v via a wet granulation technique. The weight variation, hardness, friability, disintegration time, and in-vitro drug release of the prepared famotidine tablets were then investigated.
The resulting starch is comparable to standard starch in terms of both quality and quantity. As the starch concentration was increased, the tablets' hardness and disintegration time increased. Tablets with the highest binder concentration had the highest hardness (6.0 kg) and disintegration time (8.0 min), as well as the lowest friability (0.76 percent ). Tablets containing 4% w/v starch showed the largest drug release after one hour (83.54 percent).
Conclusion: Guava starch has strong binding characteristics, according to the results of numerous studies. As a result, it can be utilised as a tablet binder in medicinal formulations.
Author(S) Details
Kushwaha Anjali
School of Pharmacy, BBD University, Lucknow, India.
Singh P. Manjul
School of Pharmacy, BBD University, Lucknow, India.
View Book:- https://stm.bookpi.org/CAPRD-V5/article/view/4940
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