Brahmi and Ginkgo biloba are two of the oldest traditional herbal remedies that are increasingly being utilised to treat age-related cognitive decline and improve cognition. The goal of this study was to see how a commercially available Brahmi, Ginkgo biloba mixture affected spatial learning and memory in healthy young albino rats.
Methodology: Wistar albino rats (n=6) weighing between 100g and 150g were used in all pharmacological tests. A total of 24 mice were screened and divided into four groups, each with six animals: Control (D.W10 ml/kg), Brahmi (40 mg/kg), Ginkgo biloba (100 mg/kg), and Piracetam 200 mg/kg. The drugs were given orally for a total of 21 days. The amnesic models and characteristics for this investigation were the Elevated Plus Maze (Transfer Latency), Open Field Test (Rearing, Locomotion), and Radial Arm Maze (Working and Reference Memory).
Transfer Latency (p=0.918) in the raised plus maze, Working memory (0.678) and Reference memory (0.984) in the radial 8 arm maze, and locomotor activity (0.920) were all non-significant after 21 days of therapy in all three groups. All parameters were non-significant in the open field apparatus.
Conclusion: The findings imply that the commercial Brahmi and Ginkgo biloba preparations we utilised in our study had no effect on several learning models as measured by the Elevated Plus Maze, Radial Arm Maze, and Open Field Test.Author(S) Details
Yogita Surendra Karandikar
Department of Pharmacology, SKNMCGH, Pune, India.
Namrata Rajendra Pawar
Department of Pharmacology, SKNMCGH, Pune, India.
Uma Anand Bhosale
Department of Pharmacology, SKNMCGH, Pune, India.
Prachi Doiphode
Department of Pharmacology, SKNMCGH, Pune, India.
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