Elevation of Glutathione-S-transferase and Inhibition of Cholinesterase Activity as a Biomarkers of Fungicide Toxicity in Mosquitofish Gambusia affinis: Experimental Investigation | Chapter 3 | New Visions in Biological Science Vol. 6

 Due to their longevity in the environment and possible impacts, pesticides have become a serious environmental problem. As a result of the effects of these chemicals, aquatic populations are vanishing all over the world. Water, in particular, is a key contamination carrier. In this study, the toxicity of ARTEA 330EC, a systemic fungicide that is being used for the first time in Algeria to combat grain pests, is assessed using two biochemical parameters: glutathione-S-transferase and cholinesterase. Gambusia affinis specimens were treated with ARTEA 330EC doses of 25, 50, 75, and 100 ppm. The average weight and size of exposed specimens have both fallen dramatically, according to the findings. Parallel to a decrease in the average rate of GSH, biochemical parameter monitoring revealed a considerable stimulating protein (Synthesis) connected with GST activity stimulation. The three fungicide concentrations show a considerable increase of acetylcholinesterase activity (25, 50 and 75ppm). Finally, our data imply that the rise in GST observed in connection with acetylcholinesterase inhibition could be used as toxicity indicators. Fungicide ARTEA 330EC in Gambusia affinis

Author(S) Details

N. Bourenane Bouhafs
Laboratoire de toxicologie cellulaire, faculté des sciences, Département de biologie, Université Badji Mokhtar, Annaba, 23000. Algérie.

M. R. Djebbar
Laboratoire de toxicologie cellulaire, faculté des sciences, Département de biologie, Université Badji Mokhtar, Annaba, 23000. Algérie.

H. Berebbeh
Laboratoire de toxicologie cellulaire, faculté des sciences, Département de biologie, Université Badji Mokhtar, Annaba, 23000. Algérie.

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