Proposal for the Modification of Plant Proteins in Order to Release Bioactive Peptides against Metabolic Syndrome | Chapter 6 | New Visions in Science and Technology Vol. 10

 Hypertension, dyslipidemia, and insulin resistance are among the illnesses that make up the metabolic syndrome. Its treatment is centred on lifestyle changes, although this approach frequently fails to improve metabolic syndrome signs over time. The sequences of certain representative vegetable proteins were investigated in order to uncover bioactive peptides with activity against metabolic syndrome illnesses. Legumin (chickpea), glutelin type A-2 (chickpea), glutelin type B-2 (rice), prolamin PPROL 17 (maize), and glutelin (rice) are five proteins that have shown to have a strong potential for preventing metabolic syndrome. After simulating gastrointestinal digestion, we created and assessed in silico alterations to their amino acid sequence to release bioactive peptides (SGD). The method described here enables the creation of proteins that could be used to treat metabolic syndrome, which can then be produced and studied afterwards. These proteins can be made through heterologous expression in bacteria or yeast, and in the long run, transgenic plants could be used to make them. These proteins may be employed as functional meals in the future.

Author(S) Details

Diego Armando Maldonado-Torres
Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, México.

D. Alejandro Fernández-Velasco
Laboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, UNAM, Ciudad de México 04510, México.

Gema Morales-Olán
Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, México.

Flor de Fátima Rosas-Cárdenas
Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, México.

Silvia Luna-Suárez
Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, México.

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