Using vacuum liquid chromatography, gel permeation chromatography, and TLC, the alkaloids ravenoline (1) and arborinine (2) were extracted from Ravenia spectabilis engl. leaf extracts. The chemicals were identified using NMR spectroscopy and a comparison of NMR data with those reported in the literature. Pure components, as well as petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF), and aqueous (AQ) soluble fractions, were used to examine the thrombolytic, antioxidant, and antibacterial characteristics of the plant's crude methanolic extract. When compared to regular streptokinase, the pure compounds and different fractions showed thrombolytic activity ranging from 30.43 to 48.85 percent in the study (74.34 percent ). All fractions and pure compounds had a modest to moderate antibacterial activity. When compared to BHT (27.50 g/ml), the carbon tetrachloride fraction showed moderate antioxidant activity (97.53 g/ml), while the other fractions showed minor antioxidant activity. The study's goal was to separate phytochemicals from Ravenia spectabilis engl. methanolic leaf extract and evaluate the bioactivities of different fractions of the plant extracts as well as isolated pure components.
Author(S) Details
Fatema Tabassum
Department of Pharmacy, Northern University Bangladesh, Dhaka-1205, Bangladesh and Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.
Choudhury Mahmood Hasan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.
Mohammad Mehedi Masud
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.
Sheikh Nazrul Islam
Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh.
Monira Ahsan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.
View Book:- https://stm.bookpi.org/CAPRD-V5/article/view/4942
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