Saturday 27 November 2021

Drug Safety Assessment in Ayurveda Clinical Trial and Practice: An Approach towards Concepts and Issues | Chapter 1 | Current Aspects in Pharmaceutical Research and Development Vol. 5

 One of the most hotly debated topics these days is the safety of Ayurvedic medicines. In Ayurveda practise and research, the magnitude of Adverse Drug Reaction (ADR) is underreported. Ayurveda has traditionally placed a premium on safe therapy, which includes alleviating symptoms while avoiding the onset of new ones. Others are unable to acquire and understand the information and terminologies described in old books. Drug safety terms are not covered in Ayurveda's undergraduate and postgraduate curricula for detecting ADR. As a result, an attempt was made to study Ayurveda's drug safety concept and issue in the light of modern pharmacology. One of the components of Rogi surakshya is drug safety, which may be related to bhesaja dosa or abhesaja. In Ayurveda, an adverse drug reaction or incident is known as dravya Vyapad, virudha, or ahita. In the year 2008, the National Pharmacovigilance Program for reporting adverse medication reactions for Ayurveda, Siddha, and Unani (ASU) pharmaceuticals was launched. In this study, the contemporary nomenclature of medication safety was introduced, as well as the component responsible for ADR. In the notion of ADR in Ayurveda medicine, the dosha vidha parikshya (Tenfold of clinical evaluation) takes a more comprehensive approach. Heavy metals in excess of allowed limits, dangerous microorganisms, pesticide residue, and aflatoxin can all be hazardous to human health. This review discusses the predictability of adverse medication reactions to metallic and plant-based pharmaceuticals. This review also discusses drug and herb interactions. The Ayurvedic medical process Panchakarma (Detoxification therapy) has the highest reported ADR in a study. The most common presenting symptoms of ADR in Ayurvedic treatment are skin rashes, diarrhoea, and vomiting. ADR faces a hurdle in standardising Ayurvedic formulations. The ADR protocol is being presented as a research and practise tool. In current clinical practise and research, this issue may provide some insight into the prevention, diagnosis, reporting, and management of adverse drug reactions.


Author(S) Details

Ashok Kumar Panda
Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneswar, Central Council of Research in Ayurveda Sciences, Ministry of AYUSH, Govt. of India, India.

Sarbeswar Kar
Department of Medical, JSS Ayurveda Medical College &Hospital, Mysore, Karnataka, India.

View Book:- https://stm.bookpi.org/CAPRD-V5/article/view/4928


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