In-vitro Bioactivity of Herbal Mixture Curcuma longa Linn, Cissus quadrangularis and Boerhaavia diffusa - An In vitro Study| Chapter 12 | Challenges and Advances in Pharmaceutical Research Vol.3

Plants are crucial in the creation of medications, and the pharmaceutical industry relies heavily on natural ingredients to create new treatments. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plant.

The goal of this study is to see if the aqua-alcoholic extract of the herbal mixture (Curcuma longa Linn + Cissus quadrangularis + Boerhaavia diffusa) has any cytotoxic, antioxidant, thrombolytic, antiinflammatory, or antibacterial activities.

Curcuma longa Linn, Cissus quadrangularis, and Boerhaavia diffusa were combined to make an aqua-alcoholic extract. Phytochemical in-vitro studies using the CCB mixture included cytotoxicity using the brine shrimp lethality assay, antioxidant activity using the DPPH assay, anti-inflammatory activity using the albumin denaturation assay, antimicrobial activity using the agar well diffusion method against Staphylococcus aureus, Streptococcus mutans, Escherichia coli, and Candida albicans, and thrombolytic activity using the clo.

The CCB mixture showed excellent cytotoxic activity at various concentrations in a brine shrimp lethality assay, boosting antioxidant activity with DPPH assay, increasing thrombolytic activity, anti-inflammatory activity, and anti-microbial activity with increasing concentration, but the anti-microbial activity was ineffective as positive controls.

In this in vitro study, the CCB combination showed significant cytotoxic, antioxidant, thrombolytic, anti-inflammatory, and antibacterial activity. More in vivo animal studies and human clinical trials are needed.

Author(s) Details:

Y. Dinesh,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

R. Abilasha,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Pratibha Ramani,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

S. Rajesh Kumar,
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6952

Phytochemical and Biological Investigations of Ravenia spectabilis engl.: A Brief Overview | Chapter 8 | Current Aspects in Pharmaceutical Research and Development Vol. 5

 Using vacuum liquid chromatography, gel permeation chromatography, and TLC, the alkaloids ravenoline (1) and arborinine (2) were extracted from Ravenia spectabilis engl. leaf extracts. The chemicals were identified using NMR spectroscopy and a comparison of NMR data with those reported in the literature. Pure components, as well as petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF), and aqueous (AQ) soluble fractions, were used to examine the thrombolytic, antioxidant, and antibacterial characteristics of the plant's crude methanolic extract. When compared to regular streptokinase, the pure compounds and different fractions showed thrombolytic activity ranging from 30.43 to 48.85 percent in the study (74.34 percent ). All fractions and pure compounds had a modest to moderate antibacterial activity. When compared to BHT (27.50 g/ml), the carbon tetrachloride fraction showed moderate antioxidant activity (97.53 g/ml), while the other fractions showed minor antioxidant activity. The study's goal was to separate phytochemicals from Ravenia spectabilis engl. methanolic leaf extract and evaluate the bioactivities of different fractions of the plant extracts as well as isolated pure components.

Author(S) Details

Fatema Tabassum
Department of Pharmacy, Northern University Bangladesh, Dhaka-1205, Bangladesh and Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.

Choudhury Mahmood Hasan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.

Mohammad Mehedi Masud
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.

Sheikh Nazrul Islam
Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh.

Monira Ahsan
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.

View Book:- https://stm.bookpi.org/CAPRD-V5/article/view/4942