In-vitro Bioactivity of Herbal Mixture Curcuma longa Linn, Cissus quadrangularis and Boerhaavia diffusa - An In vitro Study| Chapter 12 | Challenges and Advances in Pharmaceutical Research Vol.3

Plants are crucial in the creation of medications, and the pharmaceutical industry relies heavily on natural ingredients to create new treatments. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plant.

The goal of this study is to see if the aqua-alcoholic extract of the herbal mixture (Curcuma longa Linn + Cissus quadrangularis + Boerhaavia diffusa) has any cytotoxic, antioxidant, thrombolytic, antiinflammatory, or antibacterial activities.

Curcuma longa Linn, Cissus quadrangularis, and Boerhaavia diffusa were combined to make an aqua-alcoholic extract. Phytochemical in-vitro studies using the CCB mixture included cytotoxicity using the brine shrimp lethality assay, antioxidant activity using the DPPH assay, anti-inflammatory activity using the albumin denaturation assay, antimicrobial activity using the agar well diffusion method against Staphylococcus aureus, Streptococcus mutans, Escherichia coli, and Candida albicans, and thrombolytic activity using the clo.

The CCB mixture showed excellent cytotoxic activity at various concentrations in a brine shrimp lethality assay, boosting antioxidant activity with DPPH assay, increasing thrombolytic activity, anti-inflammatory activity, and anti-microbial activity with increasing concentration, but the anti-microbial activity was ineffective as positive controls.

In this in vitro study, the CCB combination showed significant cytotoxic, antioxidant, thrombolytic, anti-inflammatory, and antibacterial activity. More in vivo animal studies and human clinical trials are needed.

Author(s) Details:

Y. Dinesh,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

R. Abilasha,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Pratibha Ramani,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

S. Rajesh Kumar,
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6952

Phytochemical Evaluation and Pharmacological Screening of Coccinia grandis | Chapter 06 | Research Aspects in Biological Science Vol. 1

 Traditional medicine has employed Coccinia grandis to treat a variety of ailments. The goal of this study is to look at the phytochemical ingredients and pharmacological effects of fruit extracts from Coccinia grandis. C. grandis fruit extract was tested for antioxidant and anti-inflammatory properties in vitro. Alkaloids, carbohydrates, phytosterols, resins, tannins, flavonoids, proteins, and diterpenes were found in the phtyochemical analysis. Methanol>ethanol>petroleum ether>chloroform>n-hexane was shown to have the highest antioxidant activity. In an anti-inflammatory investigation, n-hexane and petroleum ether extracts had the most inhibitory efficacy, while chloroform extracts had the least, followed by ethanol and methanol extracts.

Author(S) Details

Shivaji Bole
PG Department of Biotechnology, The Oxford College of Science, Bangalore, India.

C. Kamatchi
PG Department of Biotechnology, The Oxford College of Science, Bangalore, India.

Neena Aloysious
PG Department of Biotechnology, The Oxford College of Science, Bangalore, India.

Linsha Lakshmanan
PG Department of Biotechnology, The Oxford College of Science, Bangalore, India.

View Book:- https://stm.bookpi.org/RABS-V1/article/view/6308