Inhibitory Effect of Compounds Isolated from the Aerial Part of Piper bavinum on Nitric Oxide Production| Chapter 7 | Current Topics on Chemistry and Biochemistry Vol. 7

 Nitric group of chemical elements (NO) is a important product and allure result is conditional nitric oxide synthases (NOSs), that involve involving reasoning from facts nitric oxide synthases (iNOS). The flood of NO by iNOS managing has been engaging attention the study of plants of various inflammatory disorders, containing poisonous shock, fabric damage, and rheumatoid arthritis. NO production inferred by lipopolysaccharide (LPS) through iNOS can indicate the point of inflammation. This study reports the antagonistic-instigative project of isolated compounds from Piper bavinum C.CD. (Piperaceae). Eight subordinate metabolites (1-8) have existed private from the aerial contained P. bavinum.  The synthetic forms of 1-8 were established principally by NMR and bulk spectra. Compound 5 was unique from P. bavinum for the first occasion.  The antagonistic-inflammatory endeavor of the unique compounds was judged against lipopolysaccharide (LPS)-induced nitric group of chemical elements (NO) result in RAW264.7 containers in vitro. Compound 4 shy LPS-persuaded NO result the most efficiently, accompanying an ic50 advantage of 5.2 M, followed by compound 5, that shy NO production accompanying an ic 50 profit of 13.5 M. Compound 4 restrained LPS-induced COX-2 and iNOS verbalization in a measure-reliant manner at the protein level. The verdicts submitted that P. bavinum and allure constituents grant permission have antagonistic-instigative properties.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City, 530000, Vietnam.

Hoang Viet Dung,
Vietnam Military Medical University, 160 Phung Hung Street, Hadong District, Hanoi 151000, Vietnam.

Tran Thi Ai My,
Department of Chemistry, University of Sciences, Hue University, Hue City, 530000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.

Please see the link here: https://stm.bookpi.org/CTCB-V7/article/view/9229

Flavonoids from Vietnamese Dalbergia oliveri and their Anti-inflammatory Activity| Chapter 5 | Current Perspectives in Agriculture and Food Science Vol. 1

 The ethyl acetate dissolved fraction of Vietnamese Dalbergia oliveri was endanger column chromatography using silica coagulate and Sephadex LH-20 to separate chemicals so that evaluate the phytochemical components and their stop of NO generation. From the heartwood of D. oliveri, nine subordinate metabolites (1–9) were successfully extracted.  The synthetic structures of these compounds were recognized as daidzein (1), formononetin (2), 3,7-dihydroxy-4¢-methoxyflavone (3), liquiritigenin (4), 3¢-methoxydaidzein (5), dalbergin (6), butin (7), sativanone (8), and isoliquiritigenin (9). The chemical structures of private compounds were identified by basic magnetic resonance dossier and comparison accompanying previously reported history. The compounds 1, 3, and 5–8 were isolated from D. oliveri for the first occasion. The anti-swelling effects of the isolated compounds on the lipopolysaccharide (LPS)-persuaded NO production in RAW 264.7 containers were measured using the Griess backlash. Compounds 7 and 9 had the strongest inhibitory project, with IC50 values of 7.6 and 11.2 μM, individually, and were followed by 3-6, that had IC50 values ranging from 19.6 to 28.7 μM. The judgments suggested that the NO-restricting properties of D. oliveri and its unaffected compounds may have antagonistic-inflammatory benefits.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City-530000, Vietnam.

Truong-Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi-122100, Vietnam.

Manh-Hung Tran,
School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City-550000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong district, Hanoi-12116, Vietnam.
Please see the link here: https://stm.bookpi.org/CPAFS-V1/article/view/8916

In-vitro Bioactivity of Herbal Mixture Curcuma longa Linn, Cissus quadrangularis and Boerhaavia diffusa - An In vitro Study| Chapter 12 | Challenges and Advances in Pharmaceutical Research Vol.3

Plants are crucial in the creation of medications, and the pharmaceutical industry relies heavily on natural ingredients to create new treatments. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plants Curcuma longa Linn, Cissus quadrangularis L., and Boerhaavia diffusa L. Curcumin is a natural compound found in the rhizomes of the plant.

The goal of this study is to see if the aqua-alcoholic extract of the herbal mixture (Curcuma longa Linn + Cissus quadrangularis + Boerhaavia diffusa) has any cytotoxic, antioxidant, thrombolytic, antiinflammatory, or antibacterial activities.

Curcuma longa Linn, Cissus quadrangularis, and Boerhaavia diffusa were combined to make an aqua-alcoholic extract. Phytochemical in-vitro studies using the CCB mixture included cytotoxicity using the brine shrimp lethality assay, antioxidant activity using the DPPH assay, anti-inflammatory activity using the albumin denaturation assay, antimicrobial activity using the agar well diffusion method against Staphylococcus aureus, Streptococcus mutans, Escherichia coli, and Candida albicans, and thrombolytic activity using the clo.

The CCB mixture showed excellent cytotoxic activity at various concentrations in a brine shrimp lethality assay, boosting antioxidant activity with DPPH assay, increasing thrombolytic activity, anti-inflammatory activity, and anti-microbial activity with increasing concentration, but the anti-microbial activity was ineffective as positive controls.

In this in vitro study, the CCB combination showed significant cytotoxic, antioxidant, thrombolytic, anti-inflammatory, and antibacterial activity. More in vivo animal studies and human clinical trials are needed.

Author(s) Details:

Y. Dinesh,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

R. Abilasha,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Pratibha Ramani,
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

S. Rajesh Kumar,
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6952

Study on Volatile Constituents, Cytotoxic Activity and Antioxidant Potential of Fixed Extracts of Copaifera luetzelburgii Harms | Chapter 2 | Current Aspects in Pharmaceutical Research and Development Vol.2

 Copaibas (Leguminosae - Caesalpinoideae) are native to Latin America's tropical regions and West Africa. Their stem barks are employed as a cicatrizing, anti-inflammatory, antiseptic, and anticancer agent in folk medicine. As a result, a phytochemical research of the qualitative and quantitative chemical composition of the volatile and fixed elements of the Copaifera luetzelburgii stem's leaves and bark is required, as well as their cytotoxicity, antioxidant capacity, and total phenol content. The goal of this study was to determine the chemical composition of volatile compounds, cytotoxic activity, and antioxidant potential of C. luetzelburgii Harms, which is abundantly spread in the Quilombola Community, municipality of So Miguel do Tapuio, State of Piau, Brazil. Hydrodistillation was used to extract the volatile components, which were then evaluated by GC-MS. LC-ESI-TOF-MS was also used to examine the ethanolic stem extract (EECC). The leaf and stem bark extracts (SBE) were screened for phytochemicals, with the SBE showing the most promise. While germacrene D (27.12 percent), -caryophilylene (16.43 percent), and germacrene B (12.58 percent) were found to be the major constituents in the essential oil from leaves (EOL), the oil of the stem bark contained -selinene (26.79 percent), 7-epi—selinene (24.73 percent), and -selinene (14.63 percent). Toxicity testing was carried out in Artemia salina, with inactive results (LC50 >1000g mL-1). The EECC had the highest total phenol content of 31.41 3.07, as well as the best antioxidant activity against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) with CE50 value of 40.11 2.31, while the ethanolic extract of copaiba leaves (EEFC) had CE50 value of 74.13 6.05, all ready for the test 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulf As a result, we believe that this work will contribute greatly to future phytochemistry and pharmacology studies on the species.

Author(s) Details

Sidney Goncalo de Lima
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal University of Piauí, 64049-550, Teresina-PI, Brazil.

Juliana de Sousa Figueredo
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal University of Piauí, 64049-550, Teresina-PI, Brazil.

Marcelo Costa dos Santos
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal University of Piauí, 64049-550, Teresina-PI, Brazil.

Allan Kayk Sales Meneses
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal University of Piauí, 64049-550, Teresina-PI, Brazil.

Marcio dos Santos Rocha
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal University of Piauí, 64049-550, Teresina-PI, Brazil.

José Galberto Martins da Costa
Graduate Program in Molecular Bioprospection, Laboratory of Natural Products Research, URCA, Crato-CE, Brazil.

Rozeverter Moreno Fernandes
Federal University of Piauí, Department of Veterinary Morphophysiology, University Campus Minister Petronio Portella, 64049-550, Teresina-PI, Brazil.

View Book :- https://stm.bookpi.org/CAPRD-V2/article/view/3950

Pharmacological Activities of Ficus racemosa and Analysis of Its Major Bioactive Polyphenols by HPLC-DAD | Chapter 6 | Highlights on Medicine and Medical Science Vol. 5

 Oxidative stress causes a variety of physiological disorders, including infectious diseases, inflammation, and cancer. The current study was carried out to investigate the antioxidant, antibacterial, and cytotoxic activity of methanol crude extracts of Ficus racemosa leaves and fruits (LCME and FCME, respectively) and to analyze its major bioactive polyphenols using HPLC-DAD. F. racemosa is used in traditional medicine in the subcontinent to treat a wide range of diseases. Methods: DPPH free radical scavenging, reducing power, total phenolic, total flavonoid, total tannin content assay, superoxide radical, hydroxyl radical, and hydrogen peroxide scavenging assays were used to assess the antioxidant capacity of the extracts. The HPLC-DAD method was used to identify and quantify bioactive polyphenols. The antibacterial activity was evaluated using the “disc diffusion” method. To determine the cytotoxic potential, a brine shrimp lethality assay was performed. Conclusion: Gallic acid, along with other phenolic constituents, may have played a significant role in the observed antioxidant, antibacterial, and cytotoxic activity.

Author (S) Details

Salma Akter Sumi
Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.

Md. Afjalus Siraj
Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA.

Amir Hossain
Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.

Md. Sagir Mia
Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.

Seagufta Afrin
Pharmacy Department, Jahangirnagar University, Dhaka 1342, Bangladesh.

Md. Mustafizur Rahman
Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.

View Book :- https://stm.bookpi.org/HMMS-V5/article/view/1731