Copaibas (Leguminosae - Caesalpinoideae) are native to Latin America's tropical regions and West Africa. Their stem barks are employed as a cicatrizing, anti-inflammatory, antiseptic, and anticancer agent in folk medicine. As a result, a phytochemical research of the qualitative and quantitative chemical composition of the volatile and fixed elements of the Copaifera luetzelburgii stem's leaves and bark is required, as well as their cytotoxicity, antioxidant capacity, and total phenol content. The goal of this study was to determine the chemical composition of volatile compounds, cytotoxic activity, and antioxidant potential of C. luetzelburgii Harms, which is abundantly spread in the Quilombola Community, municipality of So Miguel do Tapuio, State of Piau, Brazil. Hydrodistillation was used to extract the volatile components, which were then evaluated by GC-MS. LC-ESI-TOF-MS was also used to examine the ethanolic stem extract (EECC). The leaf and stem bark extracts (SBE) were screened for phytochemicals, with the SBE showing the most promise. While germacrene D (27.12 percent), -caryophilylene (16.43 percent), and germacrene B (12.58 percent) were found to be the major constituents in the essential oil from leaves (EOL), the oil of the stem bark contained -selinene (26.79 percent), 7-epi—selinene (24.73 percent), and -selinene (14.63 percent). Toxicity testing was carried out in Artemia salina, with inactive results (LC50 >1000g mL-1). The EECC had the highest total phenol content of 31.41 3.07, as well as the best antioxidant activity against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) with CE50 value of 40.11 2.31, while the ethanolic extract of copaiba leaves (EEFC) had CE50 value of 74.13 6.05, all ready for the test 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulf As a result, we believe that this work will contribute greatly to future phytochemistry and pharmacology studies on the species.
Author(s) Details
Sidney Goncalo de
Lima
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal
University of Piauí, 64049-550, Teresina-PI, Brazil.
Juliana de Sousa
Figueredo
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal
University of Piauí, 64049-550, Teresina-PI, Brazil.
Marcelo Costa dos
Santos
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal
University of Piauí, 64049-550, Teresina-PI, Brazil.
Allan Kayk Sales
Meneses
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal
University of Piauí, 64049-550, Teresina-PI, Brazil.
Marcio dos Santos
Rocha
Organic Geochemistry Laboratory, Graduate Program in Chemistry, Federal
University of Piauí, 64049-550, Teresina-PI, Brazil.
José Galberto Martins
da Costa
Graduate Program in Molecular Bioprospection, Laboratory of Natural
Products Research, URCA, Crato-CE, Brazil.
Rozeverter Moreno
Fernandes
Federal University of Piauí, Department of Veterinary Morphophysiology,
University Campus Minister Petronio Portella, 64049-550, Teresina-PI, Brazil.
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