The variability of oxygen consumption (VO2) and carbon dioxide production (VCO2), as well as the relationship between serum glucose and insulin and the energy spectral density (ESD) of VO2 and VCO2, were used to assess variations in cellular metabolism.
Materials and Methods: The study included ten non-glucose intolerant and ten glucose intolerant patients between the ages of 21 and 70. For three hours, glucose, insulin, VO2 and VCO2 levels, as well as VO2 and VCO2 levels, were assessed every 10 minutes. The ESD of VO2 and VCO2 was estimated and correlated with glucose and insulin levels.
Results: At post-load glucose state compared to basal state, there was statistical significance in glucose levels, insulin, and ESD of VO2 and VCO2 among non-glucose intolerant subjects, and glucose and insulin among glucose intolerance subjects. Furthermore, glucose levels in glucose intolerance patients were considerably greater than non-glucose intolerant subjects in both the basal and post-load glucose stages.
Conclusions: These data reveal an increase in ESD of VO2 and VCO2 in non-glucose intolerant people during the post-load glucose state, hinting that their measurement could be a crucial signal of cellular metabolic activity variability and help confirm glucose metabolism abnormalities. More research is required to fully comprehend the precise behaviour of ESD of VO2 and VCO2 in a wider group of diabetes people.
Author (S) Details
Julián Satué-Rodríguez
Medical Research Unit in Metabolic Diseases, Cardiology Hospital, National Medical Center, Mexican Institute of Social Security, México City, Mexico.
José D. Méndez
Medical Research Unit in Metabolic Diseases, Cardiology Hospital, National Medical Center, Mexican Institute of Social Security, México City, Mexico.
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