Osteosarcoma is a rare primary tumour of the bone that accounts for less than 0.2 percent of all cancer cases. When compared to medicinal plants and phytoconstituents, it is treated with advanced medications that have significant negative effects. The primary goal of this research is to investigate the antibacterial activity, phytochemical screening, and anticancer activity of Pleurotus ostreatus ethanolic concentrate. Pleurotus ostreatus' antimicrobial movement was detected using an agar well dissemination approach against two G -ve and two G +ve bacteria. The antibacterial activity intensity was assessed based on the zone of inhibition generated. The study of flavonoids, terpenoids, alkaloids, saponins, starches, tannins, amino acids, and steroids revealed the presence of flavonoids, terpenoids, alkaloids, saponins, starches, tannins, amino acids, and steroids in the ethanolic extract. The DPPH and FRAP methods were used to conduct the antioxidant test. Pleurotus ostreatus was tested in vitro for anticancer and cell toxicity against (osteosarcoma) human bone cancer cell lines and normal cell lines. The anticancer test was performed on osteosarcoma HL60 cancer cells. As a result, this research concludes that the ethanolic concentrate of Pleurotus ostreatus has antibacterial and anticancer activities.
Author(s) Details
J. Bindhu
Department of Biotechnology, Bannari Amman Institute of Technology,
Sathymangalam – 638401, Erode District, Tamil Nadu, India.
E. Vihashinee
Department of Biotechnology, Bannari Amman Institute of Technology,
Sathymangalam – 638401, Erode District, Tamil Nadu, India.
A. Rubiga
Department of Biotechnology, Bannari Amman Institute of Technology,
Sathymangalam – 638401, Erode District, Tamil Nadu, India.
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