Papain Hydrolysates of Oyster Mushroom Protein: A Novel Approach to In vitro Cancer Inhibition | Chapter 3 | Contemporary Research and Perspectives in Biological Science Vol. 6

In India, cancer ranks as the second leading cause of mortality. Cancer was a leading cause of mortality worldwide in 2020, accounting for almost 10 million fatalities. It is anticipated that the number of cancer cases will exceed 1.7 million per year by 2030. India's cancer incidence and mortality rates are predicted to rise over the next ten years, underscoring the necessity of improved prevention, early detection, and appropriate treatment approaches. In recent years, there has been a lot of interest in investigating natural compounds as possible cancer therapeutic agents. The bioactive chemicals and vital minerals found in oyster mushrooms have been connected to a number of possible health advantages, such as boosting immunity and heart health. The goal of the current study is to assess the papain hydrolysates of oyster mushroom (Pleurotus ostreatus) protein's in vitro anticancer activity. The phosphate buffer method was used to separate the protein from oyster mushrooms, and the protein content was 24 mg/g of oyster mushrooms. Papain hydrolyzed the entire protein by adding enzyme and substrate at a 1:5 ratio. Using the MTT assay, percentage cell inhibition in the MCF-7 cell line was used to examine in vitro anticancer efficacy. Vero cell lines were used to determine the in vitro percentage of cell viability. In the MCF-7 cell line, papain hydrolysates were shown to have the highest percentage of cell inhibition, 75.82% at 100 μg/ml and 89.83% at 500 μg/ml, respectively. The maximum percentage of cell viability was seen in papain hydrolysates, which were 97.23% at 100 μg/ml and 83.72% at 500 μg/ml concentrations, respectively.

 

Author (s) Details

 

Sundaram Meignanalakshmi
Department of Animal Biotechnology, Madras Veterinary College, Chennai-7, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/crpbs/v6/3011

Anticancer Activities of Spinach (Spinacia oleracea L.) - An Overview | Chapter 9 | Recent Developments in Chemistry and Biochemistry Research Vol. 4

Aims: The target of the present article is to provide a short review of the anticancer and antiproliferative function of spinach (Spinacia oleracea L.) against various cancer cell lines in vitro and in vivo. 

Background: Spinach is a significant functional food due to its rich content of vitamins and minerals, along with other bioactive chemical compounds viz., glycoglycerolipids, carotenoids, polyphenols, flavonoids, and many others.  The biological applications of spinach have received constant attention in the research field because of its interesting antioxidant, anti-inflammatory and cytotoxic properties.

Discussion: A thorough literature review has disclosed that glycoglycerolipids, carotenoids, and phenolic compounds are mainly responsible for the antineoplastic characteristics of dietary spinach. The spinach extracts have demonstrated antitumour character against various malignant cells in vitro and in vivo. The glycoglycerolipids have acted as a remarkable cytotoxic agent on both injection and oral administration in mice. One of the glycolipids present in spinach viz., mono galactosyl diacylglycerol (MGDG) has displayed a notable synergistic effect with irradiation resulting in greater shrinkage of tumour size when compared to the isolated application of MGDG and irradiation.

Conclusion: The article delineates the importance of spinach as a functional food with anticancer activity highlighting its importance in the study of new chemotherapeutic drugs.

 

Author (s) Details

 

Chhandasi Guha Roy Sarkar
Department of Chemistry, Hooghly Mohsin College, Chinsurah, Hooghly, West Bengal, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v4/1130

Examining Acetone Extracts of Toona cilliata, Seriphium plumosum and Schkuhria pinnata on Hela Cervical Cancer Cells: Anticancer Potential | Chapter 7 | Advancement and New Understanding in Medical Science Vol. 5

Background: Cervical cancer is common in women in less developed regions of the world. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combination might result in reduced toxicity and increased efficacy of the treatment regimen. At present, more than 8 South African women die from cervical cancer every day. The anti-cancer activity of the acetone extracts of S. plumosum, T. cilliata and S. pinnata was assessed using different parameters.

Methods: S. plumosum and S. pinnata were collected from Mankweng and T. cilliata from Tzaneen in Limpopo province, South Africa. An immortalized human cell line (HeLa) was used in this study and the cells were cultured and maintained in RPMI media. Secondary metabolite detection and antioxidant activity quantification were determined using the DPPH and ferric iron reducing assays. HeLa cell growth inhibition and mechanistics were assessed by employing MTT and Annexin-V flous assays.

Results: Observations revealed the presence of phenolic, flavonoids, tannins steroids and coumarins in all the plants extracts. A high amount of total phenolic and flavonoid content was detected in S. plumosum and T. cilliata. S. plumosum extract had the best DPPH scavenging activity and ferric reducing powers. The Antioxidant activity profile show S. plumosum to contain more compounds with antioxidant activity as compared to the other two plant extracts.

Conclusion: Observable concentration dependent cell proliferation inhibition by test materials was exhibited. The leaf extracts from T. cilliata, S. plumosum and S. pinnata contain compounds of various polarities with free-radicals, antioxidant and anti-cancerous activities that may play a beneficial role in treatment.

Author(s) Details:

Mxolisi Justice Ndlovu,
Department of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture, South Africa.

Victor Patrick Bagla,
Department of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture, South Africa.

Matlou Phenius Mokgotho,
Department of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture, South Africa.

Marema Ephraim Makgatho,
Department of Pathology and Medical Sciences, Faculty of Health Sciences, University of Limpopo, South Africa.

Thabe Moss Matsebatlela,
Department of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture, South Africa.

Please see the link here: https://stm.bookpi.org/ANUMS-V5/article/view/13307

Herbal Approaches to Cholangiocarcinoma: A Systematic Review | Chapter 2 | Advanced Concepts in Medicine and Medical Research Vol. 11

Cholangiocarcinoma (CCA) is a diseased bile pipe cancer of epithelial containers with high depression and mortality. The increasing incidence of cholangiocarcinoma (hostility duct tumor) and limited treatment alternatives stimulate a urgent demand for research and the development of new chemotherapeutics against cholangiocarcinoma. This phase highlights the act of herbal cure in Cholangiocarcinoma control by using a systematic review approach. This study still aimed to orderly review herbs and herb-derivative compounds or herbal formulations that have existed investigated for their anti-cholangiocarcinoma potential. Orderly literature searches were attended in three electronic databases: PubMed, Skill Direct, and Scopus. The studies were initially secluded by titles and abstracts to exclude immaterial articles and duplication. Individual hundred and twenty-three research articles completed the eligibility tests and were included in the study (68 herbs, isolated compounds and/or artificial analogs, 9 herbal formulations, and 119 compounds that are commonly in the direction of several plant variety). The most examined herb was Atractylodes lancea (Thunb.) DC. (Compositae) and Curcuma longa L. (Zingiberaceae). Only A. lancea (Thunb.) DC. (Compositae) has sustained the full process of nonclinical and clinical evolve- ment to deliver the things produced for clinical use. The extracts of A. lancea (Thunb.) DC. (Compositae), Garcinia hanburyi Hook.f. (Clusiaceae), and Piper nigrum L. (Piperaceae) exhibit antiproliferative actions against human cholangiocarcinoma cells (IC50 < 15 µg/mL). Cucurbitacin B and triptolide are herbaceous isolated compounds that exhibit ultimate promising activities (IC50 < 1 µM). A order of experimental studies (artificial, in vivo, and humans) rooted the anti-cholangiocarcinoma potential and security profile of A. lancea (Thunb.) DC. (Compositae) and its alive compounds atractylodin and β- eudesmol, including the capsule drug of the standardized A. lancea (Thunb.) DC. (Compositae) extract. Future research endure focus on the complete development of the bidder herbs to deliver safe and productive products for cholangiocarcinoma control.Future research endure be geared toward the filled development of the applicant herbs until the delivery of ending products that are dependable and effective for CCA control.

Author(s) Details:

Kesara Na-Bangchang,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand and Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand.

Tullayakorn Plengsuriyakarn,
Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand.

Juntra Karbwang,
Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Klongneung, Klongluang District, Pathumthani, Thailand.

Please see the link here: https://stm.bookpi.org/ACMMR-V11/article/view/12885

Putative Pathways of Cancer Pathophysiology, Proliferation, and Anticancer Activity of Chitosan| Chapter 1 | Current Overview on Disease and Health Research Vol. 9

 Cancer refers to the odd growth of containers with the invasive figure, mainly grown due to loss in immune defence mechanism. The rudimentary development, tumour progress and metastasis of tumor are governed by angiogenesis, that revenue under a suitable condition of the triggering of angiogenic switch accompanying a net balance between the supporting-angiogenic and anti-angiogenic determinants. The current study shows that the anticancer activity of chitosan is associated with the basic pathways of deoxyribonucleic acid (DNA) dysfunction and apoptosis, inhibition of the catalyst ribonucleotide reductase (RR), induction of complete and sudden withdrawal from an addictive substance enzymes, immunopotentiation, anti-metastasis by way of the interference in basic invasion and action, and the natural antioxidant characterization increment via the scavenging of malignancy-causing free radicals. The study of the basic pathways of anticancer activity of chitosan is important towards the synthetic customization and tailoring of chitosan biomaterial as a powerful anticancer drug candidate. The goals of the study lie on verdict the putative basic routes of cancer pathophysiology and proliferation, and the mechanistic approaches of anticancer project of chitosan that are expected expected important engaged of research, specifically on chitosan based anticancer drug formulations happening strategy.

Author(s) Details:

Hari Sharan Adhikari,
Department of Applied Sciences, Institute of Engineering, Pashchimanchal Campus, Tribhuvan University, Pokhara, Nepal.

Paras Nath Yadav,
Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal.

Please see the link here: https://stm.bookpi.org/CODHR-V9/article/view/9178

A Comprehensive Study on Anticancer Activity of Tridax procumbens Leaf Extracts on A549 and Hep G2 Cell Lines| Chapter 12 | Challenges and Advances in Pharmaceutical Research Vol. 10

 Cancer is a ailment which is harshly effecting the global human community. There is always a loyal demand for new therapies to treat and forestall this life-threatening disease. Scientific and research interest is illustration its consideration towards naturally derivative compounds, as they are considered to have less poisonous side effects compared to current situations such as a destructive agent, radiation etc. Medicinal plant Tridax procumbens produces commonly occurring secondary metabolites that is being investigated for the anticancer actions against A549 (human lung tumor cell line), Hep G2 (human liver carcinoma container line) leading to the happening of new clinical drug.MTT and trypan sky dye exclusion assays were used to assess the anticancer action of T.procumbens ethanol, acetone, and liquid leaf extracts on selected human malignant cell lines. The MTT assay relies on the skill of viable containers' mitochondrial enzymes to convert the yellow soluble seasoning MTT to the purple sad insoluble formazan precipitate, that is then characterized spectrophotometrically at 570 nm. The Trypan blue assay depends cell staining. Cells are then included under a microscope using a hemocytometer, and non-practicable cells are tainted blue while viable containers remain spotless.The aqueous leaf extract of T. procumbens has not proved any anticancer activity. However, acetone and flammable liquid leaf extracts of T. procumbens has shown forceful anticancer activity on A549 (human alveolus cancer container line), Hep G2 (human liver carcinoma cell line).T. procumbens examined for anticancer potential by MTT assay and trypan blue forbiddance assay. The acetone and ethanol leaf extracts of T. procumbens have proved potent anticancer activity on picked human cell lines.

Author(s) Details:

Pittu Vishnu Priya,
Department of Pharmaceutical Biotechnology, Joginpally B.R Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.

A. V. S. S. S. Gupta,
Department of Pharmacology, Joginpally B.R Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.

A. Srinivasa Rao,
Department of Pharmacology, Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.

Please see the link here: https://stm.bookpi.org/CAPR-V10/article/view/8828

Anti-proliferative Effect on Breast Cancer Cell Line via Novel Biogenic Peptide Functionalized Silver Nanoparticles Synthesized from Aloin | Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 8

 The current study aims to synthesise tableware( Ag) nanoparticles using Aloin with a focus on antibacterial, antioxidant, and anticancer exertion. The biosynthesis of nanoparticles has been designed as a profitable and environmentally friendly volition to chemical and physical styles.

The UV-Visible diapason was used to determine the tableware nanoparticles, which were synthesised using Aloin. Scanning electron microscopy( SEM), zeta eventuality, and dynamic light scattering( DLS) were used to further characterise it. The Aloin was also subordinated to a Fourier transfigure infraredanalysis.The immersion peak at 439nm in the UV-Visible immersion diapason of the synthesised tableware nanoparticles demonstrates the conformation of tableware nanoparticles in result. The shape of the Ag nanoparticles was revealed by SEM analysis. The IR gamuts revealed that Aloin excerpt contains six functional groups. The nanoparticles synthesised are largely stable, with an average flyspeck size of130.7 nm, as verified by zeta eventuality and DLS analysis. The nanoparticles produced were antibacterial and antioxidant in nature. It has a strong cytotoxic effect on bone cancer cell lines. According to the current study, the conflation route can be used on a large scale in the food assiduity for food preservation and these Ag nanoparticles can be used for its remedial purposes to develop a new medicine to treat cancer because it isn't dependent on factors like high energy, dragged medication times, and specialised outfit.

Author(s) Details:

F. Janeeta Priya,
PG & Research Department of Chemistry, Holy Cross College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

A. Leema Rose,
PG & Research Department of Chemistry, Holy Cross College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

S. Vidhya,
PG & Research Department of Chemistry, Holy Cross College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

A. Arputharaj,
Department of Electronics, St. Joseph’s College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/CAPR-V8/article/view/8491

Anticancer Activity of PHCUMN in Breast Cancer Cells through the Stabilization of Non-covalent Bonds| Chapter 9 | Current Practice in Medical Science Vol. 7

 

 The combination of antitumor dynamic builds is a significant focal point of interest in many exploration bunches on the planet. We need to offer not so much poisonous but rather more viable medicines. Today, the consideration of mainstream researchers is centered around specialists, that are more normal. The particle PHCUMN1 (a subordinate of heteroaromatic amino corrosive edifices), shows movement against malignant growth cells. The component of anticancer was explored liable for this medicament in cells of bosom malignant growth (in vitro testing).

PHCUMN is liable for a portion subordinate lessening and unattached development of malignant growth cells MCF-7. We explored the counter proliferative capability of PHCUMN in bosom malignant growth cell lines. It additionally explained the system of activity of PHCUMN in preclinical models of bosom disease. We explored the counter proliferative capacity of PHCUMN against disease cell. We needed to explain the component and strength of PHCUMN in preclinical examinations on malignant growth cell. PHCUMN has been displayed to have a decent impact in killing malignant growth cell. The rate fracture along the side shows the annihilation of disease cell.

PHCUMN showed great viability in killing disease cells. This is managed without a noticeable impact on typical disease cells the level of Fragmentation and atomic shrinkage plainly shows the apoptosis of cancer cells.

As indicated by referenced results, we can make inference that PHCUMN can possibly impact against disease cell. The intermolecular electrostatic cooperation between the side chains of DNA nucleobases with PHCUMN - settled the complex. The complex PHCUMN has been assessed from the accompanying harmony: DNA+ PHCUMN DNA ⇄ PHCUMN , which lies transcendently on the right site.

Author(s) Details:

Seyed Ali Akbar, Sajadi,
Sharif University of Technology, Institute of Energy, Water and Environment, Iran.

Please see the link here: https://stm.bookpi.org/CPMS-V7/article/view/7840

In silico Design, Synthesis and in vitro Anticancer Activity of Novel 4-Methylbenzаmide Derivatives Containing 2,6-Substituted Purines| Chapter 8 | Current Topics on Chemistry and Biochemistry Vol. 4

 

 A variety of diseases, including the development of several cancers, are caused by the interruption of protein kinases' normal activity. For the creation of anticancer medications, inhibition of the activity of the particular protein kinases continues to be a key target. Utilizing a variety of substituted purines and 3-(trifluoromethyl)phenyl, a novel class of putative protein kinase inhibitors 7–16 was synthesised in high yields.

In this work, the 3-(trifluoromethyl)phenyl moiety was left unreplaced while purine derivatives were connected through the N-9 atom to the methyl group of 4-methylbenzamide. Since purine is a component of ATP, it has the potential to create the required hydrogen bonds in the ATP-pocket of protein kinase. The bulk of known inhibitors contain 3-(trifluoromethyl)aniline, which is also known to have strong affinity for the kinase's allosteric site. Targeted structures, on the other hand, might be categorised as modified nucleosides where the sugar portion has been replaced with 4-methylbenzamide.

Similar to the results for sorafenib, the most promising compounds 7 and 10, which included chlorine atoms in the purine heterocycle's C-2 and C-6 locations, shown inhibitory efficacy against seven cancer cell lines. Compounds 7 and 10 had IC50 values for K562 cells of 2.27 M and 2.53 M, HL-60 cells of 1.42 M and 1.52 M, and OKP-GS cells of 4.56 M and 24.77 M, respectively. Additionally, chemicals 7 and 10 dose-dependently caused apoptosis and a G2/M phase cell cycle arrest in OKP-GS cells, halting cell division. At a concentration of 1 M, compounds 7, 9, and 10 exhibited 36 to 45 percent inhibitory action against PDGFR and PDGFR.

The findings of docking and molecular dynamics revealed that the named compounds' structures are made more favourable by the addition of a 4-methylimidazole fragment.

Author(s) Details:

Elena Kalinichenko,
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, BY-220141, 5/2 Academician V.F. Kuprevich Street, Minsk, Belarus.

Aliaksandr Faryna,
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, BY-220141, 5/2 Academician V.F. Kuprevich Street, Minsk, Belarus.

Tatyana Bozhok,
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, BY-220141, 5/2 Academician V.F. Kuprevich Street, Minsk, Belarus.


Alesya Panibrat,
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, BY-220141, 5/2 Academician V.F. Kuprevich Street, Minsk, Belarus.

Please see the link here: https://stm.bookpi.org/CTCB-V4/article/view/7813  

Study on Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II) | Chapter 5 | Challenges and Advances in Chemical Science Vol.9

The anticancer activity of 5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex against breast cancer cell lines MCF-7 and MDA-MB-231, as well as epidermoid carcinoma cell line A431, revealed that the complex helped to reduce the percentage of cell viability in all of the cell lines tested, with a notable contribution The complex and free ligand IC50 values were determined to be in the range of 0.85-1.24 M and 3.28-3.53 M, respectively. Because of its action at micromolar concentrations (IC50 0.85 M), the complex may be the superior anticancer treatment for MDA-MB-231 among those cell lines. Substitution on parent isatin and pyridyl piperazinyl rings, as well as their coordination to metal ions, can boost the anticancer effectiveness of ligands.

Author (s) Details

Narendra Kumar Singh
Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu, Nepal.


Ms. Smriti Shrestha
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.


Ms. Nerina Shahi
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.


Dr. Ravinder Kumar Choudhary
Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar-249404, India


Dr. Anupa A. Kumbhar
Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.


Yuba Raj Pokharel
Chosun University, Gwangju, South Korea.


View Book :- https://stm.bookpi.org/CACS-V9/article/view/6450

Biologically Derived Gold Nanoparticles for Pharmacological Activity | Chapter 03 | Current Aspects in Pharmaceutical Research and Development Vol. 8

 The development and characterisation of gold nanoparticles (AuNPs) for pharmacological applications such as antibacterial and anticancer actions are the focus of this research. The gold nanoparticles (GNPs) were arranged in a basic natural approach to use plant extracts. Within the show consider, the Hygrophila spinosa watery leaf extract was used. For the combination of gold nanoparticles with the plant extract H. spinosa, bioreduction of auric chloride (HAuCl4) was used. HAuCl4 is added to the plant extract. The arrangement of AuNPs inside 10 minutes at room temperature (28°C) causes auric chloride to decrease. X-ray diffraction, SEM-EDAX, DLS, FT-IR, and UV spectroscopy were used to determine the size, shape, and important investigation. The findings revealed that H. spinosa leaf extract could be an outstanding bioreductant for the union of gold nanoparticles. Gold nanoparticles that have been created are more dynamic against human infections and have excellent anti-cancer effects.

Author(S) Details

Koperuncholan M.
Department of Botany, Srimad Andavan Arts and Science College (Autonomous), Tiruchirappalli, Tamil Nadu - 620 005, India.

View Book:- https://stm.bookpi.org/CAPRD-V8/article/view/5644

Antioxidant and Anti-Osteosarcoma Effect of Edible Fungi Pleurotus ostreatus | Chapter 7 | Current Aspects in Pharmaceutical Research and Development Vol. 2

 Osteosarcoma is a rare primary tumour of the bone that accounts for less than 0.2 percent of all cancer cases. When compared to medicinal plants and phytoconstituents, it is treated with advanced medications that have significant negative effects. The primary goal of this research is to investigate the antibacterial activity, phytochemical screening, and anticancer activity of Pleurotus ostreatus ethanolic concentrate. Pleurotus ostreatus' antimicrobial movement was detected using an agar well dissemination approach against two G -ve and two G +ve bacteria. The antibacterial activity intensity was assessed based on the zone of inhibition generated. The study of flavonoids, terpenoids, alkaloids, saponins, starches, tannins, amino acids, and steroids revealed the presence of flavonoids, terpenoids, alkaloids, saponins, starches, tannins, amino acids, and steroids in the ethanolic extract. The DPPH and FRAP methods were used to conduct the antioxidant test. Pleurotus ostreatus was tested in vitro for anticancer and cell toxicity against (osteosarcoma) human bone cancer cell lines and normal cell lines. The anticancer test was performed on osteosarcoma HL60 cancer cells. As a result, this research concludes that the ethanolic concentrate of Pleurotus ostreatus has antibacterial and anticancer activities.

Author(s) Details        

J. Bindhu
Department of Biotechnology, Bannari Amman Institute of Technology, Sathymangalam – 638401, Erode District, Tamil Nadu, India.

E. Vihashinee
Department of Biotechnology, Bannari Amman Institute of Technology, Sathymangalam – 638401, Erode District, Tamil Nadu, India.

A. Rubiga
Department of Biotechnology, Bannari Amman Institute of Technology, Sathymangalam – 638401, Erode District, Tamil Nadu, India.

View Book :- https://stm.bookpi.org/CAPRD-V2/article/view/3955

Study on Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug | Chapter 6 | New Ideas Concerning Science and Technology Vol. 11

 By coupling with several arylboronic acids and methylation using two different methods, a sequence of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields. The anticancer activity of the indazole derivatives (3a-3j) and their N-methyl derivatives (5a-5j) is tested in vitro against two cancer cell lines, HCT-116 and MDA-MB-231. According to the findings, the indazole derivatives examined have mild to moderate anticancer activity against the cell lines studied. We believe that slight structural modifications to these active derivatives may result in more promising anticancer drugs, and that more experimental research, particularly in the area of anticancer research, is needed.

Author (s) Details

Jagan Mohana Rao Saketi
Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

S. N. Murthy Boddapati
Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

M. Raghuram
Department of Botany & Microbiology, Acharya Nagarjuna University, Guntur-522510, A.P., India.

Syed Farooq Adil
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

Mohammed Rafi Shaik
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

Osamah Alduhaish
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

M. Rafiq H. Siddiqui
Department of Chemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.

Hari Babu Bollikolla
Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, A.P., India.

View Book :- https://stm.bookpi.org/NICST-V11/article/view/680

Enhanced Antioxidant and Anticancer Properties of Pulsed Electric Field-treated Black Grape Extract | Chapter 1| Current Topics in Medicine and Medical Research Vol. 8

 Grape, one of the world's largest fruit crops and the world's most widely eaten fruit, is abundant in phytochemicals with antioxidants, such as polyphenols, both of which have antioxidant and anticancer effects. Several bio-active compounds include grape extract, often expressed by polyphenols and phenolic acids. It may be an ideal alternative, with the least side effects and an excellent cost-benefit ratio, to toxic chemo medications. Grape extract exerts high antioxidant and anticancer activities against cell lines of human cancer. A variety of cancers, including lung , colon, cervical, bladder, and prostate cancers, may be treated. The antioxidant and anticancer properties of the pulsed electric field (PEF) treated grape extract have been investigated in this study. For this reason, HeLa Cell Line (Cervical Cancer) was used. Compared to untreated ones, the findings suggest more antioxidant activity and more cell death due to PEF-treated extract, suggesting the enhanced potency of PEF-treated extract. This illustrates the promise of the use of grape extract treated with PEF as a possible anti-cancer drug.

Author(s) Details

V. Gowri Sree
Division of High Voltage Engineering, Department of EEE, College of Engineering, Anna University, Chennai, India..

T. Jeya Shree
Division of High Voltage Engineering, Department of EEE, College of Engineering, Anna University, Chennai, India.

A. Priyanka
Division of High Voltage Engineering, Department of EEE, College of Engineering, Anna University, Chennai, India.

Raji Sundararajan
School of Engineering Technology, Purdue University, West Lafayette, Indiana, USA.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/316