The anticancer activity of 5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex against breast cancer cell lines MCF-7 and MDA-MB-231, as well as epidermoid carcinoma cell line A431, revealed that the complex helped to reduce the percentage of cell viability in all of the cell lines tested, with a notable contribution The complex and free ligand IC50 values were determined to be in the range of 0.85-1.24 M and 3.28-3.53 M, respectively. Because of its action at micromolar concentrations (IC50 0.85 M), the complex may be the superior anticancer treatment for MDA-MB-231 among those cell lines. Substitution on parent isatin and pyridyl piperazinyl rings, as well as their coordination to metal ions, can boost the anticancer effectiveness of ligands.
Author (s) Details
Narendra Kumar Singh
Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu, Nepal.
Ms. Smriti Shrestha
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.
Ms. Nerina Shahi
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India.
Dr. Ravinder Kumar Choudhary
Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar-249404, India
Dr. Anupa A. Kumbhar
Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India.
Yuba Raj Pokharel
Chosun University, Gwangju, South Korea.
View Book :- https://stm.bookpi.org/CACS-V9/article/view/6450
No comments:
Post a Comment