Thursday, 21 April 2022

An Emerging Approach for Patient Stratification and Therapy Choice : “High” and “Low” Gene Expression Signatures in Rheumatoid Arthritis | Chapter 01 | New Horizons in Medicine and Medical Research Vol. 3

 Rheumatoid arthritis (RA) is a chronic inflammatory illness with an unknown cause that affects several immune system pathways, as well as a variety of other tissues, and is linked to joint deterioration. The pathophysiological and pharmacological factors that lead to joint deterioration and pain induction are not addressed by current treatments. Furthermore, RA patients are exceedingly diverse, necessitating specialised medications, which are difficult to choose because not all patients respond to treatment. Currently, in approximately half of RA patients, clinical, immunological, and radiological features do not allow for the prediction of anti-rheumatic medication response. According to new research, stratifying individuals based on their pro-inflammatory gene expression levels may help predict response to RA medication.


Author(S) Details


Elena V. Tchetina
Principal Investigator, Clinical Immunology Laboratory, Nasonova Research Institute of Rheumatology, 34A Kashirskoe Shosse, Moscow, 115522, Russia.

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https://stm.bookpi.org/NHMMR-V3/article/view/6330

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