SUMOylation is a reversible post-translational modification that plays a role in DNA damage repair, immunological responses, carcinogenesis, cell cycle progression, and apoptosis. SUMO1, SUMO2/3, and SUMO4 are the four SUMO isoforms that have been identified. In complicated protein regulatory networks, many levels of regulation or SUMOylation may play a crucial role. SUMOylation dysfunction can lead to the development of illnesses and malignancies. As a result, SUMO could be employed as a cancer treatment target. The small ubiquitin-like modifier (SUMO) pathway is found in all eukaryotes and is involved in gene regulation, cellular signalling, and the preservation of genomic integrity. Maturation, activation, conjugation, ligation, and de-modification are all part of the SUMO catalytic cycle. The SUMO system has been related to a number of disorders, the most prominent of which being cancer. Carcinogenesis, DNA damage response, cancer cell proliferation, metastasis, and apoptosis are all affected by SUMOylation. SUMO has the potential to be a cancer treatment target. To better comprehend the role of SUMO in human disease, we present the basic concepts of the SUMO system and summarise the involvement of SUMO proteins in cancer cells in this review.
Author(S) Details
ZhI-Jian Han
Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.
Yan-Hu Feng
Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.
Bao-Hong Gu
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.
Yu-Min Li
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.
Hao Chen
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.
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