Comprehensive Human Laboratory Immunology: Principles, Protocols and Application | Book Publisher International

The book text covers the basic principles, protocols and applications of human laboratory immunology presented in a comprehensive attitude. The nature of the material presentation was in an essay style. In general, the essay text structure starts with an abstract, introduction, inducer, immune responses, immunopathogenesis, sampling, processing, findings, interpretations, immunodiagnostic tips, conclusion and references. The essay chapter 1 described the method for the preparation of antigens. Essay 2 covered the attributes of immune competence. Immune resilience, the current update concept was stated in essay 3. The protocols for the immunization of laboratory animals were depicted in essay 4. Facts on immune simulation between mammalian laboratory animals and human beings were outlined in Essay 5. The practical aspects of the detection of immune responses were explained in essays 6 and 7. Humoral innate immunity was briefed in essays 9 and 10. Natural innate and adaptive immunity were mostly functioning in a cooperative manner. To this end, complement system studies were made in essays 11 and 12. Humoral antibody mediated immunity covering; normoglubulin, cryoglobulin and pyroglobulin were detailed in essays 13 to 15. The immunology of human bacteriosis including; typhoid, brucellosis and tuberculosis was mentioned in essays 18 to 20. The immunology of human disease conditions like; persistent pyuria, vaginosis, infertility, burns, allergy, diabetes, energy and cancer molecular immunology were presented in essays 21 to 28.

 

Author (s) Details

 

Ibrahim M S Shnawa
Department of Medical Biotechnology, College of Biotechnology, AL-Qasim Green University, Babylon, Iraq and College of Nursing, University of Hilla, Babylon, Iraq.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-78-5

Post-Translational Modification of SUMOylation and Cancer: A Brief Review | Chapter 09 | New Horizons in Medicine and Medical Research Vol. 3

 SUMOylation is a reversible post-translational modification that plays a role in DNA damage repair, immunological responses, carcinogenesis, cell cycle progression, and apoptosis. SUMO1, SUMO2/3, and SUMO4 are the four SUMO isoforms that have been identified. In complicated protein regulatory networks, many levels of regulation or SUMOylation may play a crucial role. SUMOylation dysfunction can lead to the development of illnesses and malignancies. As a result, SUMO could be employed as a cancer treatment target. The small ubiquitin-like modifier (SUMO) pathway is found in all eukaryotes and is involved in gene regulation, cellular signalling, and the preservation of genomic integrity. Maturation, activation, conjugation, ligation, and de-modification are all part of the SUMO catalytic cycle. The SUMO system has been related to a number of disorders, the most prominent of which being cancer. Carcinogenesis, DNA damage response, cancer cell proliferation, metastasis, and apoptosis are all affected by SUMOylation. SUMO has the potential to be a cancer treatment target. To better comprehend the role of SUMO in human disease, we present the basic concepts of the SUMO system and summarise the involvement of SUMO proteins in cancer cells in this review.

Author(S) Details

ZhI-Jian Han
Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.

Yan-Hu Feng
Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.

Bao-Hong Gu
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.

Yu-Min Li
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.

Hao Chen
Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R., China.

View Book:- https://stm.bookpi.org/NHMMR-V3/article/view/6338