A prevalent genetic illness in humans, autosomal dominant polycystic kidney disease (ADPKD) affects one in every 100 persons. Mutations in the PKD1 gene, which is found on human chromosome 16p13.3, account for 85% of ADPKD cases; mutations in the PKD2 gene, which is found on human chromosome 4q21-23, account for 15% of ADPKD cases. The study included 100 ADPKD patients as well as age and gender matched healthy persons. The study's goal was to compare the lipid profiles and levels of calcium (Ca), sodium (Na), iron (Fe), and potassium (K) in ADPKD patients and healthy people. The lipid profile was examined using a commercially available span kit and semiautoanalyzer (Erba, Chem 5X). Flame photometry (ELICO, CL 22D) and atomic absorption spectroscopy (ELICO, SL 173) were used to determine the amounts of Ca, Na, Fe, and K, and significant differences were found at p 0.05. Patients with ADPKD had lipid abnormalities, hyponatremia, cholesterolemia, renal osteodystrophy, cardiovascular issues, and anaemia. As a result, the study uncovers a relationship between lipid profile, calcium, sodium, iron, and potassium levels, and ADPKD in the South Indian population.
Author(S) Details
P. Veeramuthumari
Department of Zoology, V. V. Vanniaperumal College for Women, India.
View Book:- https://stm.bookpi.org/NHMMR-V3/article/view/6337
No comments:
Post a Comment