Cancer refers to the odd growth of containers with the invasive figure, mainly grown due to loss in immune defence mechanism. The rudimentary development, tumour progress and metastasis of tumor are governed by angiogenesis, that revenue under a suitable condition of the triggering of angiogenic switch accompanying a net balance between the supporting-angiogenic and anti-angiogenic determinants. The current study shows that the anticancer activity of chitosan is associated with the basic pathways of deoxyribonucleic acid (DNA) dysfunction and apoptosis, inhibition of the catalyst ribonucleotide reductase (RR), induction of complete and sudden withdrawal from an addictive substance enzymes, immunopotentiation, anti-metastasis by way of the interference in basic invasion and action, and the natural antioxidant characterization increment via the scavenging of malignancy-causing free radicals. The study of the basic pathways of anticancer activity of chitosan is important towards the synthetic customization and tailoring of chitosan biomaterial as a powerful anticancer drug candidate. The goals of the study lie on verdict the putative basic routes of cancer pathophysiology and proliferation, and the mechanistic approaches of anticancer project of chitosan that are expected expected important engaged of research, specifically on chitosan based anticancer drug formulations happening strategy.
Author(s) Details:
Hari Sharan Adhikari,
Department
of Applied Sciences, Institute of Engineering, Pashchimanchal Campus, Tribhuvan
University, Pokhara, Nepal.
Paras
Nath Yadav,
Central
Department of Chemistry, Tribhuvan University, Kathmandu, Nepal.
Please see the link here: https://stm.bookpi.org/CODHR-V9/article/view/9178
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