CD4+ICOS+Foxp3+regulatory T cells: A Novel Sub-population Associated with Pathogenesis of Malaria| Chapter 9 | Current Overview on Disease and Health Research Vol. 9

 The securing immune response and ailment outcome are known expected counterbalanced by regulatory T cells. The duty of naturally occurring supervisory cells CD4+CD25+Foxp3+ in malaria contamination remains debatable. ICOS particle has been demonstrated to imitate in the growth and function of regulatory T containers and helps T regulatory containers to produce more IL-10. This work investigates the role of ICOS-dependent supervisory CD4+ICOS+Foxp3+ T cells in resistance and susceptibleness to the malaria parasite. Here, the verbalization of CD4+ICOS+ Foxp3 + T regulatory cells in deadly and non-lethal malaria deadbeat infection was examined. During deadly infection, CD4+ICOS+ T cells increase as the affliction progress. Whereas, in non-lethal parasite contamination, along with the reduction in parasitaemia later day 7 post-infection, ICOS verbalization was also decreases. In lethal parasitical infection, the frequency of CD4 +ICOS+FoxP3+ T supervisory cells was substantially larger compared to the non-lethal parasitical infection. Moreover, there was important difference in the cytokine’s profiles of two together lethal and non-lethal contaminations. In non-lethal contamination, the expression of (IL-12) interlukin-12+ CD4+T cells was increases extensively, when compared to the lethal sickness infection. The relative frequency of IL-10+CD4+T containers was significantly higher in deadly parasite infection accompanying subsequently high antitoxin levels of IL-10 cytokines. Overall, these findings suggest that all along lethal parasite contamination, CD4+ICOS+Foxp3+ regulatory T cells encourage an immunosuppressive environment in the host immune whole, than enables the pathogen to experience and enhances parasite endurance.

Author(s) Details:

Rubika Chauhan,
Parasite-Host Biology, National Institute of Malaria Research, Dwarka, New Delhi, India.

Vikky Awasthi,
Parasite-Host Biology, National Institute of Malaria Research, Dwarka, New Delhi, India.

Reva Sharan Thakur,
Parasite-Host Biology, National Institute of Malaria Research, Dwarka, New Delhi, India.

Veena Pande,
Biotechnology Department, Kumaun University, Nainital, India.

Debprasad Chattopadhyay,
ICMR Virus Unit, ID & BG Hospital, Kolkata, 700010, India and ICMR-National Institute of Traditional Medicine (NITM), Belagavi-590010, India.

Please see the link here: https://stm.bookpi.org/CODHR-V9/article/view/9186