2-Amino-N-(Substituted Alkyl) Benzoxazole-5- Carboxamide Derivatives as Antiinflammatory and Antioxidant Drugs| Chapter 9 | Current Overview on Pharmaceutical Science Vol. 2

 The objective of the Present work is to synthesize, characterization and Pharmacological evaluation of 2-Amino-N-(substituted alkyl) benzoxazole-5- carboxamides for anti-inflammatory and antioxidant activities starting from 4-carbomethoxynitrophenol. Evaluation of the compounds showed Vc(R=ethyl), Ve(R=propyl) and Vg (R=diisopropyl) V g (R=propyl) as the most powerful ones. When compared to the standard ascorbic acid, compound Vf (R=isopropyl) demonstrated a substantially higher percentage of free radical scavenging activity with an IC 50 of 4.65. Vf is regarded as a medication that has both anti-inflammatory and antioxidant properties.

Author(s) Details:

Arunadevi Parlapalli,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

Kishore,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India

Manasa Cidda,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

Sarangapani Manda,
Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9171