Evaluation of Hepatoprotective Activity of Berberis Aristata Root Extract against Chemical-induced Acute Hepatotoxicity in Rats| Chapter 13 | Current Overview on Pharmaceutical Science Vol. 2

 Biotransformation of free radical products, increased lipid peroxidation, and overdone cell end of life are all important determinants causing liver damage persuaded by CCL4. The pharmacological properties of "berberine chloride," a root extract from Berberis aristata, contain antimicrobial, antiviral, anti-instigative, cholesterol-lowering, anticancer, and antioxidant belongings. The present study aimed to explore the deterrent and curative belongings of Berberine on liver tissue harm, liver enzymes, total bilirubin and liver weight. The study was transported at the Department of Pharmacology in collaboration accompanying the Department of Pathology and Biochemistry, MM Institute of Medical Sciences &Research, Mullana, India.  Adult wistar rats aged 7 -9 weeks were introduced with 50% CCl4 intraperitoneally as excellent:1 mixture in liquid paraffin. Berberine was executed intraperitoneally before or after CCl4 situation in various groups. Twenty-four hours subsequently CCl4 injection, levels of liver enzymes (antitoxin alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)), bilirubin and liver pressure were measured. Histological changes in the liver were too examined accompanying microscopy. The serum levels of liver enzymes and bilirubin were significantly raised (p<0.01) in CCl4-treated group 2 rats.In comparison, group 3-5 rats doctored with CCl4 attended by berberine chloride at doses of 5, 10 and 20 mg/kg, respectively, granted a significant decrease (p<0.05) in levels. The belongings of Berberine were dose-helpless in both pre-and post-situation groups. Histological examination too showed curtailed liver damage in berberine-treated groups. The current study explains that Berberine has both deterrent and curative hepatoprotective belongings against CCl4-induced hepatotoxicity. Berberine has the potential to design new situations against drug-induced hepatotoxicity.

Author(s) Details:

Navdeep Dehar,
Queens University, Kingston, Canada.

Rani Walia,
Department of Pharmacology, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.

R. B. Verma,
Department of Pharmacology, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.

Pinky Pandey,
Department of Pathology, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.

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