Aims: The target of the present article is to provide a short review of the anticancer and antiproliferative function of spinach (Spinacia oleracea L.) against various cancer cell lines in vitro and in vivo.
Background: Spinach is a significant functional food due to its
rich content of vitamins and minerals, along with other bioactive chemical
compounds viz., glycoglycerolipids, carotenoids, polyphenols, flavonoids, and
many others. The biological applications
of spinach have received constant attention in the research field because of
its interesting antioxidant, anti-inflammatory and cytotoxic properties.
Discussion: A thorough literature review has disclosed that
glycoglycerolipids, carotenoids, and phenolic compounds are mainly responsible
for the antineoplastic characteristics of dietary spinach. The spinach extracts
have demonstrated antitumour character against various malignant cells in vitro
and in vivo. The glycoglycerolipids have acted as a remarkable cytotoxic agent
on both injection and oral administration in mice. One of the glycolipids
present in spinach viz., mono galactosyl diacylglycerol (MGDG) has displayed a
notable synergistic effect with irradiation resulting in greater shrinkage of
tumour size when compared to the isolated application of MGDG and irradiation.
Conclusion: The article delineates the importance of spinach as a
functional food with anticancer activity highlighting its importance in the
study of new chemotherapeutic drugs.
Author
(s) Details
Chhandasi
Guha Roy Sarkar
Department of Chemistry, Hooghly Mohsin College, Chinsurah,
Hooghly, West Bengal, India.
Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v4/1130
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