Anti-proliferative Effect on Breast Cancer Cell Line via Novel Biogenic Peptide Functionalized Silver Nanoparticles Synthesized from Aloin | Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol. 8

 The current study aims to synthesise tableware( Ag) nanoparticles using Aloin with a focus on antibacterial, antioxidant, and anticancer exertion. The biosynthesis of nanoparticles has been designed as a profitable and environmentally friendly volition to chemical and physical styles.

The UV-Visible diapason was used to determine the tableware nanoparticles, which were synthesised using Aloin. Scanning electron microscopy( SEM), zeta eventuality, and dynamic light scattering( DLS) were used to further characterise it. The Aloin was also subordinated to a Fourier transfigure infraredanalysis.The immersion peak at 439nm in the UV-Visible immersion diapason of the synthesised tableware nanoparticles demonstrates the conformation of tableware nanoparticles in result. The shape of the Ag nanoparticles was revealed by SEM analysis. The IR gamuts revealed that Aloin excerpt contains six functional groups. The nanoparticles synthesised are largely stable, with an average flyspeck size of130.7 nm, as verified by zeta eventuality and DLS analysis. The nanoparticles produced were antibacterial and antioxidant in nature. It has a strong cytotoxic effect on bone cancer cell lines. According to the current study, the conflation route can be used on a large scale in the food assiduity for food preservation and these Ag nanoparticles can be used for its remedial purposes to develop a new medicine to treat cancer because it isn't dependent on factors like high energy, dragged medication times, and specialised outfit.

Author(s) Details:

F. Janeeta Priya,
PG & Research Department of Chemistry, Holy Cross College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

A. Leema Rose,
PG & Research Department of Chemistry, Holy Cross College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

S. Vidhya,
PG & Research Department of Chemistry, Holy Cross College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

A. Arputharaj,
Department of Electronics, St. Joseph’s College, (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/CAPR-V8/article/view/8491

Antiquorum-Sensing and Antibacterial Activity of Green Synthesized Silver Nanoparticles against Methicillin-Resistant Staphylococcus aureus (MRSA) | Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol.1

The creation of effective technologies for the green manufacture of silver nanoparticles using plant extracts has been a prominent emphasis in nanotechnology. As bacteria gain resistance to even the most powerful antibiotics, bactericidal nanomaterials are becoming increasingly essential. The discovery of a bacterial communication system (Quorum-sensing system), which orchestrates key temporal events during the infection process, has opened up a new way to treat bacterial infection that isn't based on growth suppression. This has sparked interest in the bactericidal properties of Ag+ ions and Ag-based compounds, such as silver nanoparticles (AgNPs). For the reduction of aqueous silver ions, extracellular manufacturing of silver nanoparticles was carried out utilising aqueous extracts of nine distinct herbal plant leaves in the current work. Among the nine medicinal plants tested, Aerva lanata leaf extracts demonstrated the fastest (2 min) decrease of silver ions in the solution. The morphology and architectures of the nanoparticles were studied using transmission electron microscopy, UV-visible spectroscopy, and X-ray diffraction. The nanocrystalline phase of silver was discovered by SEM and X-ray diffraction (XRD) research, with average particle sizes ranging from 37 to 47 nm and determined to be spherical. Furthermore, the produced AgNPs showed significant antibacterial efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA). Furthermore, the stable silver nanoparticles decreased violacein synthesis in Chromobacterium violaceum CV026, which is a quorum-sensing controlled behaviour.

Author(s) Details:

M. Arunkumar,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.


M. Safana Farjeen,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.


S. K. Divya,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.


T. Jeyadoss,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.

Please see the link here: https://stm.bookpi.org/CAPR-V1/article/view/6234