Antiquorum-Sensing and Antibacterial Activity of Green Synthesized Silver Nanoparticles against Methicillin-Resistant Staphylococcus aureus (MRSA) | Chapter 3 | Challenges and Advances in Pharmaceutical Research Vol.1

The creation of effective technologies for the green manufacture of silver nanoparticles using plant extracts has been a prominent emphasis in nanotechnology. As bacteria gain resistance to even the most powerful antibiotics, bactericidal nanomaterials are becoming increasingly essential. The discovery of a bacterial communication system (Quorum-sensing system), which orchestrates key temporal events during the infection process, has opened up a new way to treat bacterial infection that isn't based on growth suppression. This has sparked interest in the bactericidal properties of Ag+ ions and Ag-based compounds, such as silver nanoparticles (AgNPs). For the reduction of aqueous silver ions, extracellular manufacturing of silver nanoparticles was carried out utilising aqueous extracts of nine distinct herbal plant leaves in the current work. Among the nine medicinal plants tested, Aerva lanata leaf extracts demonstrated the fastest (2 min) decrease of silver ions in the solution. The morphology and architectures of the nanoparticles were studied using transmission electron microscopy, UV-visible spectroscopy, and X-ray diffraction. The nanocrystalline phase of silver was discovered by SEM and X-ray diffraction (XRD) research, with average particle sizes ranging from 37 to 47 nm and determined to be spherical. Furthermore, the produced AgNPs showed significant antibacterial efficacy against Methicillin-Resistant Staphylococcus aureus (MRSA). Furthermore, the stable silver nanoparticles decreased violacein synthesis in Chromobacterium violaceum CV026, which is a quorum-sensing controlled behaviour.

Author(s) Details:

M. Arunkumar,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.


M. Safana Farjeen,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.


S. K. Divya,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.


T. Jeyadoss,
Department of Chemistry & Biosciences, Srinivasa Ramanujan Centre, SASTRA Deemed University, Kumbakonam, Tamil Nadu - 612001, India.

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