The goal of this research was to create new gel X-ray contrast agents (RCA) with tantalates of rare-earth elements or solid solutions based on them in micro and nanoscale states. The next goal was to give a gradual rise in contrast, which would improve diagnostic accuracy while lowering patient radiation dose. As such, the orthotantalats MTaO4 (M = Y, La, Gd) and solid solutions La1-xGdxTaO4 were investigated. In vitro and in vivo tests were performed on the RCA. When gel lanthanum orthotantalate was used as an RCA for bile passage contrast studies, it had a high resolving power in the evaluation of the hepatic tree and gallbladder, as well as in the diagnosis of intracavitory tumours in the ducts and gallbladder. Unlike iodine-containing urografin, this RCA has no adverse effects on the mucosal tunic of laboratory animals' bile channels. By gradually changing the composition and average size of the material particles, one can adjust the specific effectiveness of RCA using substitutional solid solutions.
Author (S) Details
M. G. Zuev
Institute of Solid State Chemistry, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia.
L. P. Larionov
Ural State Medical University, 620219, Ekaterinburg, Russia.
I. M. Strekalov
The Central City Clinical Hospital No 1, 620026, Ekaterinburg, Russia.
E. Yu. Zhuravleva
Ural Federal University Named After the First President of Russia B.N. Yeltsin, 620002 Ekaterinburg, Russia.
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