Flavonoids from Vietnamese Dalbergia oliveri and their Anti-inflammatory Activity| Chapter 5 | Current Perspectives in Agriculture and Food Science Vol. 1

 The ethyl acetate dissolved fraction of Vietnamese Dalbergia oliveri was endanger column chromatography using silica coagulate and Sephadex LH-20 to separate chemicals so that evaluate the phytochemical components and their stop of NO generation. From the heartwood of D. oliveri, nine subordinate metabolites (1–9) were successfully extracted.  The synthetic structures of these compounds were recognized as daidzein (1), formononetin (2), 3,7-dihydroxy-4¢-methoxyflavone (3), liquiritigenin (4), 3¢-methoxydaidzein (5), dalbergin (6), butin (7), sativanone (8), and isoliquiritigenin (9). The chemical structures of private compounds were identified by basic magnetic resonance dossier and comparison accompanying previously reported history. The compounds 1, 3, and 5–8 were isolated from D. oliveri for the first occasion. The anti-swelling effects of the isolated compounds on the lipopolysaccharide (LPS)-persuaded NO production in RAW 264.7 containers were measured using the Griess backlash. Compounds 7 and 9 had the strongest inhibitory project, with IC50 values of 7.6 and 11.2 μM, individually, and were followed by 3-6, that had IC50 values ranging from 19.6 to 28.7 μM. The judgments suggested that the NO-restricting properties of D. oliveri and its unaffected compounds may have antagonistic-inflammatory benefits.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City-530000, Vietnam.

Truong-Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi-122100, Vietnam.

Manh-Hung Tran,
School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City-550000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong district, Hanoi-12116, Vietnam.
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