Many instinctive products have happened shown to have cytotoxicity and are secondhand as chemotherapy powers for anticancer. The current study was designed to evaluate the cytotoxic action of chemical parts from the whole plant of Isodon ternifolius. A recently oxygenated spiroketone, isodonspiroketone (1) and four famous ones (2-5) were private. Using NMR, MS, and CD spectrum dossier, the structure of isodonspiroketone (1) was discovered. Isolation of compound 3 from I. ternifolius has not still occurred. In vitro tests were accomplished on their cytotoxic effects on the malignancy cell lines MDA-MB-231, HepG2, and A549. New compound (isodonspiroketone, 1) disclosed moderate cytotoxic activities against A549, HepG2, and MDA-MB-231 malignancy cell lines accompanying IC50 values of 23.84 ± 2.73, 27.77 ± 3.01, and 17.26 ± 1.61 μM, respectively, meantime, the others were lazy.
Author(s) Details:
Nguyen Thi Ai Nhung,
Department
of Chemistry, University of Sciences, Hue University, Hue City, Hue 530000,
Vietnam.
Tran
Thi Ai My,
Department
of Chemistry, University of Sciences, Hue University, Hue City, Hue 530000,
Vietnam.
Minh-Quan Pham,
Institute of Natural Products Chemistry, Vietnam Academy of Science
and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam and
Graduate University of Science and Technology, Vietnam Academy of Science and
Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam.
Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science
and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam and
Graduate University of Science and Technology, Vietnam Academy of Science and
Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam.
Dao-Cuong
To,
Phenikaa
University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong
District, Hanoi 12116, Vietnam.
Please see the link here: https://stm.bookpi.org/CERB-V2/article/view/8891
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