Inhibitory Effect of Compounds Isolated from the Aerial Part of Piper bavinum on Nitric Oxide Production| Chapter 7 | Current Topics on Chemistry and Biochemistry Vol. 7

 Nitric group of chemical elements (NO) is a important product and allure result is conditional nitric oxide synthases (NOSs), that involve involving reasoning from facts nitric oxide synthases (iNOS). The flood of NO by iNOS managing has been engaging attention the study of plants of various inflammatory disorders, containing poisonous shock, fabric damage, and rheumatoid arthritis. NO production inferred by lipopolysaccharide (LPS) through iNOS can indicate the point of inflammation. This study reports the antagonistic-instigative project of isolated compounds from Piper bavinum C.CD. (Piperaceae). Eight subordinate metabolites (1-8) have existed private from the aerial contained P. bavinum.  The synthetic forms of 1-8 were established principally by NMR and bulk spectra. Compound 5 was unique from P. bavinum for the first occasion.  The antagonistic-inflammatory endeavor of the unique compounds was judged against lipopolysaccharide (LPS)-induced nitric group of chemical elements (NO) result in RAW264.7 containers in vitro. Compound 4 shy LPS-persuaded NO result the most efficiently, accompanying an ic50 advantage of 5.2 M, followed by compound 5, that shy NO production accompanying an ic 50 profit of 13.5 M. Compound 4 restrained LPS-induced COX-2 and iNOS verbalization in a measure-reliant manner at the protein level. The verdicts submitted that P. bavinum and allure constituents grant permission have antagonistic-instigative properties.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City, 530000, Vietnam.

Hoang Viet Dung,
Vietnam Military Medical University, 160 Phung Hung Street, Hadong District, Hanoi 151000, Vietnam.

Tran Thi Ai My,
Department of Chemistry, University of Sciences, Hue University, Hue City, 530000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.

Please see the link here: https://stm.bookpi.org/CTCB-V7/article/view/9229

Flavonoids from Vietnamese Dalbergia oliveri and their Anti-inflammatory Activity| Chapter 5 | Current Perspectives in Agriculture and Food Science Vol. 1

 The ethyl acetate dissolved fraction of Vietnamese Dalbergia oliveri was endanger column chromatography using silica coagulate and Sephadex LH-20 to separate chemicals so that evaluate the phytochemical components and their stop of NO generation. From the heartwood of D. oliveri, nine subordinate metabolites (1–9) were successfully extracted.  The synthetic structures of these compounds were recognized as daidzein (1), formononetin (2), 3,7-dihydroxy-4¢-methoxyflavone (3), liquiritigenin (4), 3¢-methoxydaidzein (5), dalbergin (6), butin (7), sativanone (8), and isoliquiritigenin (9). The chemical structures of private compounds were identified by basic magnetic resonance dossier and comparison accompanying previously reported history. The compounds 1, 3, and 5–8 were isolated from D. oliveri for the first occasion. The anti-swelling effects of the isolated compounds on the lipopolysaccharide (LPS)-persuaded NO production in RAW 264.7 containers were measured using the Griess backlash. Compounds 7 and 9 had the strongest inhibitory project, with IC50 values of 7.6 and 11.2 μM, individually, and were followed by 3-6, that had IC50 values ranging from 19.6 to 28.7 μM. The judgments suggested that the NO-restricting properties of D. oliveri and its unaffected compounds may have antagonistic-inflammatory benefits.

Author(s) Details:

Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City-530000, Vietnam.

Truong-Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi-122100, Vietnam.

Manh-Hung Tran,
School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City-550000, Vietnam.

Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong district, Hanoi-12116, Vietnam.
Please see the link here: https://stm.bookpi.org/CPAFS-V1/article/view/8916