Neuroprotective Effects of Natural Plant Extracts (Ginkgo biloba, Curcuma longa, and Withania somnifera) in Parkinson’s Disease Models: A Meta-Analysis | Chapter 10 | Disease and Health: Research Developments Vol. 8

Parkinson's disease (PD) is a neurological illness that deteriorates over a period and usually impairs movement. Natural plant extracts have gained increasing interest in recent times because of their potential to provide neuroprotection. This study performs a meta-analysis of the neuroprotective advantages supplied by natural plant extracts, putting considerable focus on Ginkgo biloba, Curcuma longa, and Withania somnifera, as tested in diverse PD models. A systematic literature exploration was undertaken through electronic databases, together with PubMed, Scopus, Web of Science, and Google Scholar, for the period from January 2000 to August 2024. The principal ways in which these substances function have been identified as antioxidant activity, anti-inflammatory effects, and the modulation of neurotransmitter levels. Curcuma longa and Ginkgo biloba each showed remarkable antioxidant and anti-inflammatory properties, and Curcuma longa, in particular, reduced oxidative stress and inflammation via curcumin-mediated neuroprotection. The management of mitochondrial function and the balance of neurotransmitters has indicated neuroprotective features associated with Withania somnifera. Dopaminergic neuron loss is a key feature of Parkinson’s disease, and protecting these neurons or boosting dopamine synthesis is critical for neuroprotection. Several included studies found that Ginkgo biloba enhanced dopamine levels in the striatum and therefore modulated dopamine metabolism. Despite successful results in preclinical research, the leap to clinical implementation is challenging due to difficulties with bioavailability and the requirement for standardized extracts. This article highlights the potential therapeutic benefits of natural extracts such as PD-supportive treatments, but it also emphasizes the need for more studies—clinical studies in particular—to determine these extracts' effectiveness in treating human populations.

 

Author (s) Details

Naik GS
AIIMS Mangalagiri, India.

 

Raja Gulfam Shaikh
Department of Neurology, Super Speciality Hospital, M.G.M. Medical College, Indore, India.

 

Satish P Dipankar
Department of Physiology, AIIMS Mangalagiri, India.

 

J M Kanthi Thilaka
Aditya University, Surampalem, A.P, India.

 

Heena Sharma
DDMCOP University- HPTU, India.

 

Deep Sharma
DDMCOP, Una University-HPTU, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v8/4833

Assessment of Commercially Available Preparation of Brahmi, Ginkgo biloba on Cognitive Functions in Rats: A Comparative Study | Chapter 10 | Current Aspects in Pharmaceutical Research and Development Vol. 5

 Brahmi and Ginkgo biloba are two of the oldest traditional herbal remedies that are increasingly being utilised to treat age-related cognitive decline and improve cognition. The goal of this study was to see how a commercially available Brahmi, Ginkgo biloba mixture affected spatial learning and memory in healthy young albino rats.

Methodology: Wistar albino rats (n=6) weighing between 100g and 150g were used in all pharmacological tests. A total of 24 mice were screened and divided into four groups, each with six animals: Control (D.W10 ml/kg), Brahmi (40 mg/kg), Ginkgo biloba (100 mg/kg), and Piracetam 200 mg/kg. The drugs were given orally for a total of 21 days. The amnesic models and characteristics for this investigation were the Elevated Plus Maze (Transfer Latency), Open Field Test (Rearing, Locomotion), and Radial Arm Maze (Working and Reference Memory).

Transfer Latency (p=0.918) in the raised plus maze, Working memory (0.678) and Reference memory (0.984) in the radial 8 arm maze, and locomotor activity (0.920) were all non-significant after 21 days of therapy in all three groups. All parameters were non-significant in the open field apparatus.

Conclusion: The findings imply that the commercial Brahmi and Ginkgo biloba preparations we utilised in our study had no effect on several learning models as measured by the Elevated Plus Maze, Radial Arm Maze, and Open Field Test.

Author(S) Details

Yogita Surendra Karandikar
Department of Pharmacology, SKNMCGH, Pune, India.

Namrata Rajendra Pawar
Department of Pharmacology, SKNMCGH, Pune, India.

Uma Anand Bhosale
Department of Pharmacology, SKNMCGH, Pune, India.

Prachi Doiphode
Department of Pharmacology, SKNMCGH, Pune, India.

View Book:- https://stm.bookpi.org/CAPRD-V5/article/view/4945