Studies on Increased Prevalence of Hernia, Uterine Descent, Fibrous Adhesions, Retroperitoneal Fibrosis and Germ Cells with Endogenous Estrogen | Chapter 11 | Highlights on Medicine and Medical Science Vol. 8

 Background: Increased prevalence of hernias, uterine descent, fibrous adhesions manifesting as colic abdominal pain, retroperitoneal fibrosis, intestinal obstruction, and volvulus were observed during the era of contraception and abortions [20th, 21st century] adopted as family welfare schemes.

The researchers wanted to see if there was an altruistic link between contraception and increased hernias, uterine descent, fibrous adhesions advancing to retroperitoneal fibrosis, volvulus, and intestinal obstructions.

Methods: In 2012, a retrospective analysis of the prevalence of hernia, uterine descent, in 350 patients aged 20-35 years, 35-50 years, and >50 years, from data collected by convenient, stratified random sampling, from various geographical locations, between 2003 and 2012, and its association with the presence, absence, and abortion was carried out; concurrently, serum oestrogen levels were measured.

Between 2000 and 2012, 25 individuals were found to have fibrous adhesions, related intestinal obstruction, volvulus, and retroperitoneal fibrosis in clinical practise; they were evaluated to see if there was a link between contraception, hysterectomy, and a cholesterol-restricted diet.

Results: With a p value of 0.0025 in 20-35 years, p value of 0.0005 in 35-50 years, and p value of 0.02 in >50 years, there was a 3-6 fold increase in hernia in contraceptive users aged >20 to >50 years: Fig. 2.

With a p value of 0.0005, there was an 8- 9 fold increase in the prevalence of fibrous adhesions in contraception users aged 20 to 50 years, and a 2 fold rise in retroperitoneal fibrosis and volvulus in those taking contraception and following hysterectomy with a p value of 0.025: Figure 1

In 61 percent of contraceptive users, endogenous oestrogen levels were below normal, and 25% of contraceptive users had low normal serum oestrogen levels with a p value of 0.0005: Figure 3: A low-cholesterol diet was linked to a 50 percent rise in degenerative illnesses, including volvulus with fibrous adhesions, leading to decreased synthesis of endogenous oestrogen androgen.

Conclusion: The concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous oestrogen: androgen, resulting in defaulted genomic repertoire, deranged cell cycle, cell metabolism, and increased degenerative pathologies such as hernia, uterine descent, and fibrous adhesions progressing to volvulus, retroperitoneal fibrosis, intestinal obstruction, and mesenteric fibrosis.

Corrective operations combined with tubal recanalisation: contraceptive reversal was achieved without recurrence or problems by restoration of genetic repertoire-figure supplemental file

Author (s) Details

Elizabeth JeyaVardhini Samuel
Karpagam Faculty of Medical Sciences and Research, Madras University, Tamilnadu, India.

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An Advanced Study on Increasing Incidence of Diabetes Mellitus, Systemic Hypertension and Germ Cells with Endogenous Estrogen | Chapter 5 | Highlights on Medicine and Medical Research Vol. 2

Context: Contraceptive age, abortions,[20th, 21st centuries] introduced as family welfare programs, increased global incidence of type 2 diabetes mellitus, systemic hypertension has been observed. Systemic hypertension was growing in the global incidence of diseases like diabetes mellitus; thus, an altruistic study was designed to determine whether there was any correlation with contraception and increasing incidence of diseases, namely diabetes mellitus, systemic hypertension.

Objectives: Systemic hypertension, an altruistic correlation of contraception [if any] with growing diabetes mellitus, was pursued. Methods: In 2012, retrospective study of, prevalence of diabetes mellitus, systemic hypertension, in 350 patients of 20 - 35 years, 35 - 50 years, >50 years, age groups, data obtained by easy, stratified random sampling, from different geographical locations, between 2003-2012 and its connection with involvement, absence of contraception, abortion was undertaken; simultaneously, serum estrogen.

Results: Type 2 diabetes mellitus increased by 10 to 45 times in contraceptive users from >20 years to >50 years; systemic hypertension increased by 15 to 50 times in contraceptive users from >20 years to >50 years. In 75% of contraceptive users, endogenous estrogen was reduced to below average and 25% of contraceptive users had low normal serum estrogen. Cholesterol deficient diet, androgen was also associated with a 50 percent rise in diabetes mellitus, systemic hypertension, due to reduced endogenous estrogen synthesis.

Conclusion: acquired contraceptive definition, abortion status, shattered germ cell fragmentation, decreased endogenous estrogen, androgen, results in default genomic repertoire, deranged cell metabolism, increased diabetes mellitus occurrence, metabolic syndrome systemic hypertension. The reversal of contraception declined as a cause and successful phenomenon of the diseases.

Author (s) Details

Elizabeth Jeya Vardhini Samuel
Department of General Medicine, Karpagam Faculty of Medical Sciences and Research, Coimbatore-32, Tamil Nadu, India.

View Book :- https://stm.bookpi.org/HMMR-V2/issue/view/20