Telmisartan Induced Myotoxicity | Chapter 3 | Novel Aspects on Pharmaceutical Research Vol. 3

 Drug-persuaded myopathy, a disease at which point taking certain drugs can diminish or destroy powers. Although the prevalence concerning this illness brought on for one drug Telmisartan is unknown, it is popular that 150 different pharmaceuticals, containing statins, corticosteroids, anti-retroviral situations, and immunosuppressants, have been linked to myotoxicity. Guidelines warn therapeutic drug listening, which is usually evaluating the levels of the medication in a patient's distribution, to manage the risk of drug-inferred myopathy linked to Telmisartan. Additionally, it concede possibility be highlighted that using Telmisartan is indulged with a slightest rise in blood creatinine, a synthetic produced by influence tissue, of up to 20–30%. However, it is considered to stop the therapy if the antitoxin creatinine level rises by more than 30%. The case defined in the paragraph involves a patient the one was thought to have knowledgeable an adverse drug reaction (ADR) to the hypertension treatment Telmisartan. The ADR with Telmisartan was driven to be "Probable" later conducting a origin analysis utilising Naranjo's treasure and the WHO-UMC Scale. As a result, the drug was removed and replaced accompanying Enalapril. The new drug helped the patient's condition, and after lab experiment revealed that the patient's levels of uric acid and creatinine were both inside normal ranges. The division focuses on how critical it is to closely monitor pharmacological medicine, especially when it includes prolonged use, so that protect victims. Myotoxicity, a rare but serious antagonistic drug reaction, was the particular ADR connected to the drug Telmisartan in this place instance. To prevent additional toxicity, Telmisartan was not administered to the patient repeated.

Author(s) Details:

Rajesh Hadia,
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara-391760, Gujarat, India.

Rahul Trivedi,
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara-391760, Gujarat, India.

Cyril Sajan,
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara-391760, Gujarat, India.

Varunsingh Saggu,
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara-391760, Gujarat, India.

Sunil Baile,
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara-391760, Gujarat, India.

Sunil Kardani,
Sunil Kardani

Hemraj Singh Rajput,
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara-391760, Gujarat, India.

Please see the link here: https://stm.bookpi.org/NAPR-V3/article/view/10878

The Comparative Study Showing of the Effect of Telmisartan and Ramipril on Diabetic Profile in Hypertensive Pre-Diabetic Patients | Chapter 10 | Technological Innovation in Pharmaceutical Research Vol. 8

 Background: Hypertension, a prevalent cardiovascular disease, is rapidly being linked to other co-morbid disorders such as diabetes mellitus, which worsens its prognosis. Telmisartan and ramipril are both antihypertensive medications. The efficacy of telmisartan and ramipril in managing or avoiding the progression of pre-diabetes to diabetes in stage 1 hypertension patients is compared in this study. It also seeks to compare the effects of Telmisartan and Ramipril on FBS and HbA1C in males and females across a 12-month treatment period.

Methods: A 12-month prospective, randomised, single-center, comparative observational study on stage 1 hypertension patients with pre-diabetes is done. A total of 60 individuals are enlisted and assigned to one of two therapy groups. They were given the designated medicine for a 12-month period and were followed up on. Blood pressure was taken and a diabetes profile was checked at each appointment.

The results of this study demonstrated that both telmisartan and ramipril efficiently regulated blood pressure. In stage 1 hypertension individuals with pre diabetes, telmisartan reduced the progression of fasting blood sugar and glycosylated haemoglobin better than ramipril.

Conclusions: Both telmisartan and ramipril had an effect on blood pressure regulation. In stage 1 hypertension patients with pre diabetes, telmisartan has a statistically significant benefit in delaying the progression of prediabetes to diabetes mellitus when compared to ramipril.

Author (s) Details

Abdullah Ansari
Department of Pharmacology, Ayaan Institute of Medical Sciences, Moinabad, Telangana, India.

Ayesha Raoof
Department of Medicine, HAL Medical Centre, Hyderabad, Telangana, India.

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Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats | Chapter 1 | Technological Innovation in Pharmaceutical Research Vol. 7

 The purpose of this study was to look into the protective effects of telmisartan against 5-FU-induced cardiotoxicity in Wister rats. Methods: Thirty-six Wister rats were divided into six groups at random: I, a negative control who received normal saline (2 ml/kg) orally for 30 days; II, a positive control who received normal saline (2 ml/kg/day) orally for 25 days and then received 5-Fluorouracil (5-FU) (20 mg in 2 ml normal saline per kg body weight) once daily by intraperitoneal injection in conjunction with normal saline. saline for 5 days; I and, receiving telmisartan (5mg and 10mg/kg/day) for 30 consecutive days; and, receiving telmisartan (5mg and 10mg/kg/day) orally for 25 days, and then receiving 5-FU (20 mg in 2ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for 5 days. Telmisartan prophylactic treatment significantly reduces serum cardiac troponin T, aspartate aminotransferase (AST), and alanine levels. Elevated aminotransferase (ALT) due to 5-FU-induced cardiotoxicity. Conclusion: The current findings suggest that telmisartan may be a useful modulator in the prevention of 5-FU-induced cardiotoxicity.

Author (S) Details

Alaa Radhi Khudhair
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Intesar T. Numan
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

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Studies on Anti-Inflammatory and General Glucocorticoid Physiology in Skeletal Muscles Affected by Duchenne Muscular Dystrophy: An approach towards Exploration of Steroid-Sparing Agents | Chapter 4 | Current Advances in Chemistry and Biochemistry Vol. 7

 The activation of proinflammatory and metabolic biological pathways in skeletal muscle cells is a hallmark of Duchenne muscular dystrophy (DMD). The dystrophin-associated protein complex, a large transmembrane protein complex that acts as a shock absorber during muscle contraction, a receiver and transducer of cellular signals, and a scaffold for signalling proteins, is destabilised in the absence of dystrophin, a protein that provides a link between the extracellular matrix and the myocyte cytoskeleton. The majority of these pathways are inhibited by synthetic glucocorticoids. Hypertension, arrhythmias, hyperglycemia, osteoporosis, weight gain, growth retardation, skin thinning, cushingoid look, and tissue-specific glucocorticoid resistance are all side effects of glucocorticoids. As a result, reducing the glucocorticoid dosage for DMD patients may be advantageous. When looking for compounds that can accomplish similar pathway stabilisation in DMD, a deeper understanding of the primary cellular pathways that are stabilised following synthetic glucocorticoid administration is required. This review gives a quick rundown of the primary anti-inflammatory pathways as well as the metabolic effects of glucocorticoids in DMD-affected skeletal muscle. The known medicines that can stabilise these pathways and could be used as steroid-sparing medicines in combination with glucocorticoid therapy are outlined. This could open up new avenues for research in DMD animal models and/or human trials, potentially resulting in lower glucocorticoid dose regimens for DMD patients.

Author (s) Details

Sandrine Herbelet
Department of Head and Skin, Division of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Arthur Rodenbach
Department of Head and Skin, Division of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Boel De Paepe
Department of Head and Skin, Division of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium and Neuromuscular Reference Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Jan L. De Bleecker
Department of Head and Skin, Division of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium and Neuromuscular Reference Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

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Determination of Telmisartan and Hydrochlorothiazide Using HPTLC in Human Plasma: Development and Validation of Bioanalytical Method | Chapter 3 | Current Advances in Chemistry and Biochemistry Vol. 7

 A simple, sensitive, quick, and cost-effective thin layer chromatographic technique was used to determine the concentrations of telmisartan and hydrochlorothiazide in human plasma using paracetamol as an internal reference. A combination of hydrochlorothiazide (HCT) and telmisartan (TEL) is more successful than either medicine alone in the treatment of hypertension.

The plasma sample was collected using a methanol-acetonitrile (3.0:0.1, v/v) mixture. Concentrations of 200, 400, 600, 800, 1000, and 1200 ng/spot were employed for the hydrochlorothiazide and telmisartan calibration curves, respectively. Telmisartan and hydrochlorothiazide, respectively, showed 75.98 percent and 81.91 percent recovery. Chloroform: methanol: toluene (8:2:4 v/v/v) makes up the mobile phase. At a wavelength of 278 nm, densitometric analysis was performed. The Rf values for hydrochlorothiazide, paracetamol, and telmisartan, respectively, were 0.28 0.05, 0.50 0.05, and 0.66 0.05. The stability of telmisartan and hydrochlorothiazide in plasma was validated in three freeze-thaw cycles (20 C), on bench for 24 hours, and post preparative for 48 hours. A recovery study was used to statistically validate the recommended method for identifying telmisartan and hydrochlorothiazide in human plasma. The method is less expensive and faster than previously disclosed approaches. In the future, we may be able to use this technique for bioequivalence research.

Author (s) Details

Ambadas R. Rote
Department of Pharmaceutical Chemistry, MGV's Pharmacy College, Pune University, Nashik, India.

Poonam R. Sonavane
Department of Pharmaceutical Chemistry, MGV's Pharmacy College, Pune University, Nashik, India.

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