Scale-Up of Green Synthesis and Characterization of Silver Nanoparticles Using Ethanol Extract of Plantago major L. Leaf and Its Antibacterial Potential: A Recent Study | Chapter 04 | Challenges and Advances in Chemical Science Vol. 8

 Because of its eco-friendly, easy, and cost-effective nature, green synthesis of silver nanoparticles (Ag NPs) using plant extracts is now widely optimised. The purpose of this work was to assess the scale-up trial of Plantago major L. leaf ethanolic extract in the green synthesis of Ag NPs in terms of synthesis parameter and centrifugation duration. The optimal scale-up condition of green synthesis was determined to be 0.25 percent leaf extract concentration, 70°C temperature, 60 minutes of synthesis time, and 30 minutes of centrifugation time. Various spectroscopic (UV-Vis, EDS, FTIR), microscopic (SEM, FE-TEM), and other investigations confirmed that the scale-up trial produced spherical silver nanoparticles with an average size of 12.25.11 nm (SAED, DLS, XRD). At a dosage of 20 g mL-1, the produced Ag NPs show good antibacterial action against numerous microorganisms tested. At the same time as a smaller scale of green synthesis, this work provides a nine-fold higher yield of produced Ag NPs (107.26.82 mg). A sufficient number of nanoparticles will allow for efficient characterisation as well as bioactivity testing and formulation research in cosmetics, medical ointments, and other pharmaceutical items.  

Author(S) Details

Johan Sukweenadhi
Department of Plant Biotechnology, Faculty of Biotechnology, University of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya 60293, East Java, Indonesia.

Kezia Irianti Setiawan
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya 60293, East Java, Indonesia.

Christina Avanti
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya 60293, East Java, Indonesia.

Kartini Kartini
Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya 60293, East Java, Indonesia.

Esrat Jahan Rupa
Department of Oriental Medicinal Biotechnology, College of Life Sciences, Kyung Hee University, Giheung-gu, Yongin-si, Gyeonggi-do, Yongin, 446–701, Republic of Korea.

Deok-Chun Yang
Department of Oriental Medicinal Biotechnology, College of Life Sciences, Kyung Hee University, Giheung-gu, Yongin-si, Gyeonggi-do, Yongin, 446–701, Republic of Korea.

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