Mesenchymal Stem Cells for Treating Ocular Surface Diseases: A Review | Chapter 01 | Issues and Developments in Medicine and Medical Research Vol. 9

 Background: Ocular surface diseases are one of the most common causes of vision impairment or blindness. In cell therapy and regenerative medicine, mesenchymal stem cells (MSC) have sparked a lot of interest. They are not only widely available, but also have strong differentiating capacities and immunosuppressive qualities. Because of their propensity to evade host immunological rejection, they are commonly employed in allografts. Clinical trials using MSC for the treatment of a variety of disorders that are resistant to conventional therapy are now underway. Several studies have been conducted on the use of MSC in the treatment of corneal abnormalities, with extremely encouraging results.

Critical Issues: Currently, the wide range of MSC isolation and expansion techniques makes it difficult to assess cell treatment ability and establish new treatment regimens.

Future Research: Future research should focus on developing international standards for MSC isolation and characterization. Furthermore, tissue engineering and regenerative medicine techniques for corneal regeneration have shown to be promising. Direct cell/growth factor delivery and hydrogel/non-hydrogel-based scaffolds are the two basic kinds of regenerative methods. We examine current MSC developments in this review, as well as the need for more research to fully realise the potential of an MSC-based cell therapy for treating ocular surface illnesses.

Author(S) Details

Sahar M. M. Omar
Faculty of Medicine, Armed Forces College of Medicine, Ain Shams University, Cairo, Egypt.

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