Implication of rs1026611 in the MCP-1 Gene and V64I of CCR2 in Stroke among SCA Tunisian Patients: A Brief Study | Chapter 1 | Issues and Developments in Medicine and Medical Research Vol.10

 Sickle cell anaemia can lead to stroke, which is a serious and potentially fatal consequence. The underlying pathogenic process of SCA, namely the blockage of tiny capillaries by malformed sickled cells, makes strokes difficult to explain. We looked studied whether single nucleotide polymorphisms (SNPs) in the MCP-1 and CCR2 genes, alone or in combination, are linked to the development of Cerebrovascular Accidents (AVC) in SCA Tunisian patients. We looked studied whether single nucleotide polymorphisms (SNPs) in the MCP-1 and CCR2 genes, alone or in combination, are linked to the development of Cerebrovascular Accidents (AVC) in SCA Tunisian patients.

Methods and Materials: In this study, 100 SCA patients were included, 19 of them had AVC. Transcranial Doppler ultrasonography was used to make a clinical diagnosis of stroke (TCD). PCR/RFLP was used to genotype rs1026611 in the MCP-1 gene and V64I in the CCR2 gene.
Results: There was no link between the SNPs investigated and the prevalence of AVC in SCA Tunisian patients, according to our data.

Author(s) Details:

Leila Chaouch,
Pasteur Institute of Tunis, Tunisia.

Miniar Kalai,
Pasteur Institute of Tunis, Tunisia.

Manel Ben Jbara,
Pasteur Institute of Tunis, Tunisia.

Imen Darragi,
Pasteur Institute of Tunis, Tunisia.

Dorra Chaouachi,
Pasteur Institute of Tunis, Tunisia.

Imen Boudrigua,
Pasteur Institute of Tunis, Tunisia.

Raouf Hafsia,
Pasteur Institute of Tunis, Tunisia.

Salem Abbes,
Pasteur Institute of Tunis, Tunisia.

Please see the link here:  https://stm.bookpi.org/IDMMR-V10/article/view/5810