Hemolytic disease of the newborn (HDN), which has a significant risk of foetal loss, is becoming less common as a result of universal iso-sensitization screening and the proper use of antenatal anti-Rh D antibody prophylaxis. HDN can also be caused by antibodies that aren't Rh D. We occasionally come with a highly sensitive foetus in the United States, resulting in severe morbidity and mortality. In utero RBC transfusions and intravenous immunoglobulin (IVIG) therapy for such an infant can help manage HDN to some extent. Partial exchange transfusions (soon after delivery) and double volume exchange transfusions are rarely used as rescue options, but they are nevertheless necessary. The best outcome of such pregnancies requires a coordinated, well-planned, and executed effort between the perinatal centre and the community health care team. It's also critical to understand the significance and efficiency of universal screening.
Author(S) Details
Raja R. Nandyal
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
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