New drug delivery systems (NDDS) are being developed in order to increase therapeutic efficacy, give maximum benefit to patients, and reduce adverse drug reactions. The creation of novel effective delivery systems for local anaesthetics (LAs) modulates the release rate, extends their anaesthetic action, and aids in their intended localization. Local anaesthetic delivery routes (epidural, peripheral, wound catheters, intra-nasal, intra-vesical, intra-articular, intra-osseous) are all being explored these days. To improve local anaesthetic permeation, various methods such as iontophoresis, electroporation, sonophoresis, and magnetophoresis are utilised. Adjuvants are used to increase the potency of a drug's effects. The use of various delivery systems should aid in keeping the LA at the target region for longer periods of time, hence prolonging the anaesthetic or analgesic action with a wider range of agents. By primarily modifying the sensory component, new drug delivery techniques for local anaesthetic give superior analgesia and anaesthesia. These innovative methods improve the efficacy and tolerance of medications.
Author(S) Details
Anshu Gupta
Department of Pharmacology Maharishi Markandeshwar Institute of Medical Science and Research MMDU Mullana, India.
Diwanshu Sharma
Department of Pharmacology, ASCOMS, Jammu, India.
View Book:- https://stm.bookpi.org/IDMMR-V8/article/view/5822
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