The scope of drug delivery technology is vast, and it is always evolving at breakneck pace. In the last few decades, lipid nanocarriers have emerged as a very promising, emerging, and fast evolving technology for the administration of numerous medications with low solubility, bioavailability, and stability. According to recent studies, roughly 40% of newer medications have such issues. Liposomes and other vesicular systems were once considered lipid carriers, but they are now classified as colloidal nano lipid-based carriers (CNLBC). Newer lipid nanocarriers, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLCs), lipid drug conjugates (LDCs), and pharmacosomes, have shown greater importance in avoiding the limitations of these CNLBCs in pH- and enzyme-dependent degradation, especially when taken orally, or in physical and chemical-related stability issues, due to low toxicity, improved bioavailability, high biocompatibility, high drug-loading Because nanostructured lipid carriers and SLNs are biodegradable, they are non-toxic. Furthermore, they are extremely stable. This review discusses the morphology, structural properties, materials utilised in manufacture, production procedures, and characterisation using various methods of their (nano-structured lipid carriers and SLNs). Although lipids and surfactants are used to make nano-structured lipid carriers and SLNs, the effect of these two matrixes in the construction of excipients is also examined, as well as their pharmacological importance in innovative theranostic techniques, stability, and storage. Both hydrophilic and lipophilic drugs can be loaded into lipid nanocarriers. In the case of lipophilic medicines (BCS Class II and IV), solubility is a rate-limiting phase that can be considerably influenced by the use of lipid nanocarriers. Lipidic nanocarriers can also increase the permeability of most hydrophilic medicines (BCS I and III class), which is the rate-limiting step in this situation. These carriers also have a well-controlled and target-specific drug delivery system, which draws researchers' attention. The current chapter intends to offer a special concern linked to numerous forms of lipid nanocarriers, their precise composition, various techniques of manufacture, and the impact of various types of lipids on the various features of such carriers. It also discusses the physicochemical, formulation, pharmacokinetic, and cytotoxic properties of these carriers. It also covers marketed lipid nanocarrier compositions, as well as their corporate and marketing names.
Author(S) Details
K. Ramesh Reddy
Department of Pharmaceutics, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh-517506, India.
V. Jayasankar Reddy
Department of Pharmacology, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati, Andhra Pradesh-517506, India.
Sucharitha Palagati
Department Pharmaceutics, Seven Hills College of Pharmacy, Venkatramapuram, Tanapalli Tirupati, Andhra Pradesh-517561, India.
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